skip to main content
Language:

Subthreshold Amyloid Predicts Tau Deposition in Aging

Leal, Stephanie L ; Lockhart, Samuel N ; Maass, Anne ; Bell, Rachel K ; Jagust, William J

The Journal of neuroscience, 2018-05, Vol.38 (19), p.4482-4489 [Peer Reviewed Journal]

United States: Society for Neuroscience

Full text available

Citations Cited by
  • Title:
    Subthreshold Amyloid Predicts Tau Deposition in Aging
  • Author: Leal, Stephanie L ; Lockhart, Samuel N ; Maass, Anne ; Bell, Rachel K ; Jagust, William J
  • Subjects: Accumulation ; Adults ; Aging ; Alzheimer's disease ; Biomarkers ; Cortex ; Deposition ; Memory ; Neurodegenerative diseases ; Older people ; Pathology ; Positron emission ; Positron emission tomography ; Scanning ; Tau protein ; Tomography ; β-Amyloid
  • Is Part Of: The Journal of neuroscience, 2018-05, Vol.38 (19), p.4482-4489
  • Notes: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Author contributions: S.L.L. and W.J.J. designed research; S.L.L., S.N.L., A.M., and W.J.J. performed research; S.L.L., S.N.L., A.M., and R.K.B. analyzed data; S.L.L. wrote the paper.
  • Description: Current approaches to the early detection of Alzheimer's disease (AD) rely upon classifying individuals as "positive" or "negative" for biomarkers related to the core pathology of β-amyloid (Aβ). However, the accumulation of Aβ begins slowly, years before biomarkers become abnormal. We used longitudinal [ C] Pittsburgh Compound B PET scanning and neuropsychological assessment to investigate the earliest changes in AD pathology and how it affects memory in cognitively normal older humans ( = 71; mean age 75 years; 35% male). We used [ F] AV-1451 PET scanning at the end of the observation period to measure subsequent tau deposition in a subset of our sample ( = 37). We found evidence for an inverted-U relationship between baseline Aβ levels and Aβ slope in asymptomatic older adults, suggesting a slowing of Aβ accumulation even in cognitively normal adults. In participants who were nominally amyloid negative, both the rate of amyloid accumulation and the baseline levels of Aβ predicted early tau deposition in cortical Braak regions associated with AD. Amyloid measures were only sensitive to memory decline as baseline levels of Aβ increased, suggesting that pathological accumulation occurs before impacting memory. These findings support the necessity of early intervention with amyloid-lowering therapies even in those who are amyloid negative. The progressive nature of Alzheimer's disease (AD) necessitates the earliest possible detection of pathological or cognitive change if disease progression is to be slowed. We examined cognitively normal older adults in whom AD pathology is starting to develop, with the goal of early detection of AD pathology or cognitive changes. We found amyloid measures to be sensitive early on in predicting subsequent early tau deposition. Further, it appears that rates of amyloid accumulation already begin to slow in preclinical AD, suggesting that it is a relatively late stage of AD progression. Thus, it is crucial to examine older adults early, before amyloid levels have saturated, to intervene to slow disease progression.
  • Publisher: United States: Society for Neuroscience
  • Language: English
Links
Back to results list
Go to Previous pagePrevious Result  5 NextGo to Next page

  • Implemented by: ABCD-USP USP   Social Network Logos: Freepik

Searching Remote Databases, Please Wait

  • Searching for
  • inscope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
  • Show me what you have so far