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Technical note: Comparison of 3 methods for analyzing areas under the curve for glucose and nonesterified fatty acids concentrations following epinephrine challenge in dairy cows

Cardoso, F.C. ; Sears, W. ; LeBlanc, S.J. ; Drackley, J.K.

Journal of dairy science, 2011-12, Vol.94 (12), p.6111-6115 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Technical note: Comparison of 3 methods for analyzing areas under the curve for glucose and nonesterified fatty acids concentrations following epinephrine challenge in dairy cows
Autor: Cardoso, F.C. ; Sears, W. ; LeBlanc, S.J. ; Drackley, J.K.
Assuntos: Animal productions ; Animals ; Area Under Curve ; area under the curve ; Biological and medical sciences ; blood ; blood glucose ; Blood Glucose - analysis ; Cattle ; dairy cows ; epinephrine ; Epinephrine - administration & dosage ; Epinephrine - pharmacology ; Fatty Acids, Nonesterified - blood ; Female ; Food industries ; free fatty acids ; Fundamental and applied biological sciences. Psychology ; glucose ; Injections, Intravenous - veterinary ; intravenous injection ; Least-Squares Analysis ; Milk and cheese industries. Ice creams ; niacin ; Niacin - pharmacology ; nonesterified fatty acid ; Terrestrial animal productions ; Vertebrates
É parte de: Journal of dairy science, 2011-12, Vol.94 (12), p.6111-6115
Notas: http://dx.doi.org/10.3168/jds.2011-4627
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Descrição: The objective of the study was to compare 3 methods for calculating the area under the curve (AUC) for plasma glucose and nonesterified fatty acids (NEFA) after an intravenous epinephrine (EPI) challenge in dairy cows. Cows were assigned to 1 of 6 dietary niacin treatments in a completely randomized 6×6 Latin square with an extra period to measure carryover effects. Periods consisted of a 7-d (d 1 to 7) adaptation period followed by a 7-d (d 8 to 14) measurement period. On d 12, cows received an i.v. infusion of EPI (1.4μg/kg of BW). Blood was sampled at −45, −30, −20, −10, and −5min before EPI infusion and 2.5, 5, 10, 15, 20, 30, 45, 60, 90, and 120min after. The AUC was calculated by incremental area, positive incremental area, and total area using the trapezoidal rule. The 3 methods resulted in different statistical inferences. When comparing the 3 methods for NEFA and glucose response, no significant differences among treatments and no interactions between treatment and AUC method were observed. For glucose and NEFA response, the method was statistically significant. Our results suggest that the positive incremental method and the total area method gave similar results and interpretation but differed from the incremental area method. Furthermore, the 3 methods evaluated can lead to different results and statistical inferences for glucose and NEFA AUC after an EPI challenge.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Technical note: Comparison of 3 methods for analyzing areas under the curve for glucose and nonesterified fatty acids concentrations following epinephrine challenge in dairy cows

Cardoso, F.C. ; Sears, W. ; LeBlanc, S.J. ; Drackley, J.K.

New York, NY: Elsevier Inc

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