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An emerging focus on lipids in extracellular vesicles

Skotland, Tore ; Sagini, Krizia ; Sandvig, Kirsten ; Llorente, Alicia

Advanced drug delivery reviews, 2020, Vol.159, p.308-321 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    An emerging focus on lipids in extracellular vesicles
  • Autor: Skotland, Tore ; Sagini, Krizia ; Sandvig, Kirsten ; Llorente, Alicia
  • Assuntos: Cellular membranes ; Exosomes ; Extracellular vesicles ; Lipidomics ; Lipids ; Secretion ; Vesicular transport
  • É parte de: Advanced drug delivery reviews, 2020, Vol.159, p.308-321
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Extracellular vesicles contain a lipid bilayer membrane that protects the encapsulated material, such as proteins, nucleic acids, lipids and metabolites, from the extracellular environment. These vesicles are released from cells via different mechanisms. During recent years extracellular vesicles have been studied as possible biomarkers for different diseases, as biological nanoparticles for drug delivery, and in basic studies as a tool to understand the structure of biological membranes and the mechanisms involved in vesicular trafficking. Lipids are essential molecular components of extracellular vesicles, but at the moment our knowledge about the lipid composition and the function of lipids in these vesicles is limited. However, the interest of the research community in these molecules is increasing as their role in extracellular vesicles is starting to be acknowledged. In this review, we will present the status of the field and describe what is needed to bring it forward. [Display omitted]
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês;Norueguês
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