skip to main content
Idioma:
Primo Advanced Search
Primo Advanced Search Query Term
Primo Advanced Search prefilters
Busca Simples

Pushing the limits of radiotherapy for atypical and malignant meningioma

Katz, Teri S ; Amdur, Robert J ; Yachnis, Anthony T ; Mendenhall, William M ; Morris, Christopher G

American journal of clinical oncology, 2005-02, Vol.28 (1), p.70-74 [Periódico revisado por pares]

United States

Texto completo disponível

Citações Citado por
  • Título:
    Pushing the limits of radiotherapy for atypical and malignant meningioma
  • Autor: Katz, Teri S ; Amdur, Robert J ; Yachnis, Anthony T ; Mendenhall, William M ; Morris, Christopher G
  • Assuntos: Adult ; Aged ; Aged, 80 and over ; Dose Fractionation, Radiation ; Female ; Humans ; Male ; Meningeal Neoplasms - radiotherapy ; Meningioma - radiotherapy ; Middle Aged ; Radiosurgery ; Survival Rate
  • É parte de: American journal of clinical oncology, 2005-02, Vol.28 (1), p.70-74
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The purpose of this study was to report the outcome of an extremely aggressive radiotherapy program in patients with atypical and malignant meningioma (60 Gy at 1.5 Gy per fraction twice daily +/- radiosurgery boost). Thirty-six patients received radiotherapy with curative intent between 1984 and 1999 for atypical (27 patients) or malignant (9 patients) meningioma. All patients had a minimum of 2 years follow up. The overall 5-year local control, cause-specific survival, and absolute survival rates were 45%, 39%, and 36%, respectively. Accelerated hyperfractionated radiotherapy resulted in a local control rate of 45% compared with 50% for patients treated with less aggressive schedules (P = 0.99). A radiosurgery boost did not improve tumor control. The complication rate for those treated with accelerated hyperfractionated radiotherapy was dramatically higher (grade 3-5: 55% vs. 0%, grade 4-5: 27% vs. 0%. both P <0.05). Our data suggests that 50 to 60 Gy delivered with conventional, once-daily fractionation is probably the optimal schedule for atypical and malignant meningioma. More aggressive radiotherapy fractionation schedules and radiosurgery are unlikely to improve outcome.
  • Editor: United States
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  5

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.