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Recurrent acquired ocular toxoplasmosis associated with Kyrieleis plaques and documented allergy to sulfonamide—A treatment proposal for two rare conditions

Amato, Valdir Sabbaga ; Ribeiro, Victoria Stadler Tasca ; Silva, Allan Gomes ; Gomes, André Marcelo Vieira ; Tuon, Felipe Francisco

Diagnostic microbiology and infectious disease, 2024-07, Vol.109 (3), p.116266-116266, Article 116266 [Periódico revisado por pares]

United States: Elsevier Inc

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Recurrent acquired ocular toxoplasmosis associated with Kyrieleis plaques and documented allergy to sulfonamide—A treatment proposal for two rare conditions
Autor: Amato, Valdir Sabbaga ; Ribeiro, Victoria Stadler Tasca ; Silva, Allan Gomes ; Gomes, André Marcelo Vieira ; Tuon, Felipe Francisco
Assuntos: Adult ; Antiprotozoal Agents - adverse effects ; Antiprotozoal Agents - therapeutic use ; Brazil ; Clindamycin - therapeutic use ; Drug Hypersensitivity - etiology ; Female ; Humans ; Inflammation ; Kyrieleis plaques ; Ocular toxoplasmosis ; Prednisone - therapeutic use ; Pyrimethamine - adverse effects ; Pyrimethamine - therapeutic use ; Recurrence ; Sulfonamides - adverse effects ; Sulfonamides - therapeutic use ; Toxoplasmosis, Ocular - drug therapy ; Treatment ; Treatment Outcome ; Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects ; Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
É parte de: Diagnostic microbiology and infectious disease, 2024-07, Vol.109 (3), p.116266-116266, Article 116266
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
Descrição: The aim of this study was to describe a case of a patient with ocular toxoplasmosis, which has resulted in Kyrieleis plaques formation (segmental periarteritis associated with severe inflammation) and later follow-up and alternative treatment due to documented allergy to sulfonamide. A 33-year-old Brazilian woman diagnosed with acute toxoplasmosis, initially treated with sulfonamide, developed a critical cutaneous rash. Cotrimoxazole was changed to clindamycin and pyrimethamine, and prednisone was started. The medication was maintained for 45 days. Four months later, she developed retinal lesions suggestive of toxoplasmosis with Kyrieleis plaques in the upper temporal vessels. Pyrimethamine, clindamycin, and prednisone were initiated until healing. She presented reactivation months later, and a suppressive treatment with pyrimethamine was instituted for one year. This is the first report to use the combination of clindamycin with pyrimethamine in the treatment and recurrence prophylaxis for OT in a documented allergy to sulfonamide.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Recurrent acquired ocular toxoplasmosis associated with Kyrieleis plaques and documented allergy to sulfonamide—A treatment proposal for two rare conditions

Amato, Valdir Sabbaga ; Ribeiro, Victoria Stadler Tasca ; Silva, Allan Gomes ; Gomes, André Marcelo Vieira ; Tuon, Felipe Francisco

United States: Elsevier Inc

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