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Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models

Domingos, Luana B ; Silva, Nicole R ; Chaves Filho, Adriano J M ; Sales, Amanda J ; Starnawska, Anna ; Joca, Sâmia

Genes, 2022-11, Vol.13 (11), p.2165 [Periódico revisado por pares]

Switzerland: MDPI AG

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Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models
Autor: Domingos, Luana B ; Silva, Nicole R ; Chaves Filho, Adriano J M ; Sales, Amanda J ; Starnawska, Anna ; Joca, Sâmia
Assuntos: 20th century ; anxiety ; Cannabidiol ; Cannabidiol - pharmacology ; Cannabidiol - therapeutic use ; Cannabinoids ; Cannabis ; Care and treatment ; Cell cycle ; Computer Simulation ; depression ; DNA methylation ; DNA Methylation - genetics ; DNMT ; Enzymes ; Epigenetics ; FDA approval ; Gene expression ; Health aspects ; Homeostasis ; Humans ; Ion channels ; Marijuana ; Mental disorders ; Mental illness ; Methylation ; Neurobiology ; Neurosciences ; Neurotransmitter receptors ; Physiological aspects ; Psychiatry ; Psychological aspects ; Review ; Schizophrenia ; stress ; Tetrahydrocannabinol ; THC
É parte de: Genes, 2022-11, Vol.13 (11), p.2165
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
These authors contributed equally to this work.
Descrição: Cannabidiol (CBD) is a non-psychotomimetic compound present in cannabis sativa. Many recent studies have indicated that CBD has a promising therapeutic profile for stress-related psychiatric disorders, such as anxiety, schizophrenia and depression. Such a diverse profile has been associated with its complex pharmacology, since CBD can target different neurotransmitter receptors, enzymes, transporters and ion channels. However, the precise contribution of each of those mechanisms for CBD effects is still not yet completely understood. Considering that epigenetic changes make the bridge between gene expression and environment interactions, we review and discuss herein how CBD affects one of the main epigenetic mechanisms associated with the development of stress-related psychiatric disorders: DNA methylation (DNAm). Evidence from in vivo and in silico studies indicate that CBD can regulate the activity of the enzymes responsible for DNAm, due to directly binding to the enzymes and/or by indirectly regulating their activities as a consequence of neurotransmitter-mediated signaling. The implications of this new potential pharmacological target for CBD are discussed in light of its therapeutic and neurodevelopmental effects.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models

Domingos, Luana B ; Silva, Nicole R ; Chaves Filho, Adriano J M ; Sales, Amanda J ; Starnawska, Anna ; Joca, Sâmia

Switzerland: MDPI AG

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