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role of macrophage migration inhibitory factor on glucose metabolism and diabetes

Toso, C ; Emamaullee, J. A ; Merani, S ; Shapiro, A. M. J

Diabetologia, 2008-11, Vol.51 (11), p.1937-1946 [Periódico revisado por pares]

Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag

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Título:
role of macrophage migration inhibitory factor on glucose metabolism and diabetes
Autor: Toso, C ; Emamaullee, J. A ; Merani, S ; Shapiro, A. M. J
Assuntos: Adaptive immunity ; Apoptosis ; Biological and medical sciences ; Blood Glucose - metabolism ; Cell adhesion & migration ; Cytokine ; Cytokines ; Diabetes ; Diabetes Mellitus - blood ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - physiopathology ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Glucose ; Glucose - metabolism ; Homeostasis ; Human Physiology ; Humans ; Inflammation ; Inflammation - physiopathology ; Insulin resistance ; Internal Medicine ; Islet transplantation ; Kinases ; Lymphocytes ; Macrophage Migration-Inhibitory Factors - physiology ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Physiology ; Proteins ; Review ; Signal transduction ; Transplants & implants
É parte de: Diabetologia, 2008-11, Vol.51 (11), p.1937-1946
Notas: http://dx.doi.org/10.1007/s00125-008-1063-3
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Descrição: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in many inflammatory reactions and disorders, and it has become evident that it also affects glucose homeostasis. The protein is produced by pancreatic beta cells and can promote the release of insulin. It also modulates glucose uptake, glycolysis and insulin resistance in insulin target cells such as the adipocyte, myocyte and cardiomyocyte. Possessing both immunological and endocrinological properties, MIF has been associated with the development of type 1 and type 2 diabetes, and it may be important in the setting of islet transplantation. The present review summarises our current knowledge, based on clinical and research data, on the impact of MIF on both physiological and pathological aspects of glucose metabolism.
Editor: Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Idioma: Inglês

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role of macrophage migration inhibitory factor on glucose metabolism and diabetes

Toso, C ; Emamaullee, J. A ; Merani, S ; Shapiro, A. M. J

Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag

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