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Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains

Ruiz, Jerônimo C ; D'Afonseca, Vívian ; Silva, Artur ; Ali, Amjad ; Pinto, Anne C ; Santos, Anderson R ; Rocha, Aryanne A M C ; Lopes, Débora O ; Dorella, Fernanda A ; Pacheco, Luis G C ; Costa, Marcília P ; Turk, Meritxell Z ; Seyffert, Núbia ; Moraes, Pablo M R O ; Soares, Siomar C ; Almeida, Sintia S ; Castro, Thiago L P ; Abreu, Vinicius A C ; Trost, Eva ; Baumbach, Jan ; Tauch, Andreas ; Schneider, Maria Paula C ; McCulloch, John ; Cerdeira, Louise T ; Ramos, Rommel T J ; Zerlotini, Adhemar ; Dominitini, Anderson ; Resende, Daniela M ; Coser, Elisângela M ; Oliveira, Luciana M ; Pedrosa, André L ; Vieira, Carlos U ; Guimarães, Cláudia T ; Bartholomeu, Daniela C ; Oliveira, Diana M ; Santos, Fabrício R ; Rabelo, Élida Mara ; Lobo, Francisco P ; Franco, Glória R ; Costa, Ana Flávia ; Castro, Ieso M ; Dias, Sílvia Regina Costa ; Ferro, Jesus A ; Ortega, José Miguel ; Paiva, Luciano V ; Goulart, Luiz R ; Almeida, Juliana Franco ; Ferro, Maria Inês T ; Carneiro, Newton P ; Falcão, Paula R K ; Grynberg, Priscila ; Teixeira, Santuza M R ; Brommonschenkel, Sérgio ; Oliveira, Sérgio C ; Meyer, Roberto ; Moore, Robert J ; Miyoshi, Anderson ; Oliveira, Guilherme C ; Azevedo, Vasco Mokrousov, Igor

PloS one, 2011-04, Vol.6 (4), p.e18551-e18551 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains
Autor: Ruiz, Jerônimo C ; D'Afonseca, Vívian ; Silva, Artur ; Ali, Amjad ; Pinto, Anne C ; Santos, Anderson R ; Rocha, Aryanne A M C ; Lopes, Débora O ; Dorella, Fernanda A ; Pacheco, Luis G C ; Costa, Marcília P ; Turk, Meritxell Z ; Seyffert, Núbia ; Moraes, Pablo M R O ; Soares, Siomar C ; Almeida, Sintia S ; Castro, Thiago L P ; Abreu, Vinicius A C ; Trost, Eva ; Baumbach, Jan ; Tauch, Andreas ; Schneider, Maria Paula C ; McCulloch, John ; Cerdeira, Louise T ; Ramos, Rommel T J ; Zerlotini, Adhemar ; Dominitini, Anderson ; Resende, Daniela M ; Coser, Elisângela M ; Oliveira, Luciana M ; Pedrosa, André L ; Vieira, Carlos U ; Guimarães, Cláudia T ; Bartholomeu, Daniela C ; Oliveira, Diana M ; Santos, Fabrício R ; Rabelo, Élida Mara ; Lobo, Francisco P ; Franco, Glória R ; Costa, Ana Flávia ; Castro, Ieso M ; Dias, Sílvia Regina Costa ; Ferro, Jesus A ; Ortega, José Miguel ; Paiva, Luciano V ; Goulart, Luiz R ; Almeida, Juliana Franco ; Ferro, Maria Inês T ; Carneiro, Newton P ; Falcão, Paula R K ; Grynberg, Priscila ; Teixeira, Santuza M R ; Brommonschenkel, Sérgio ; Oliveira, Sérgio C ; Meyer, Roberto ; Moore, Robert J ; Miyoshi, Anderson ; Oliveira, Guilherme C ; Azevedo, Vasco
Mokrousov, Igor
Assuntos: Biology ; Corynebacterium pseudotuberculosis - genetics ; Corynebacterium pseudotuberculosis - pathogenicity ; Economic impact ; Emerging markets ; Etiology ; Evolution, Molecular ; Genes ; Genome, Bacterial ; Genomes ; Goats ; Horizontal transfer ; Impact analysis ; Infections ; Inventions ; Iron ; Islands ; Livestock ; Lymphadenitis ; Pathogenicity ; Pathogenicity islands ; Pathogens ; Pseudotuberculosis ; Sheep ; Species ; Toxins ; Virulence ; Virulence - genetics ; Virulence factors
É parte de: PloS one, 2011-04, Vol.6 (4), p.e18551-e18551
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Conceived and designed the experiments: JCR AS MPC RJM AM GCO VA. Performed the experiments: FAD SB MITF GCO AM VA VD EMC LMO MCP SRCD AFC JFA. Analyzed the data: JCR AS RJM GCO AM VA VD ARS FAD LGCP MZT NS TLPC JM AZ SCS SSA VACA DMR. Contributed reagents/materials/analysis tools: VA GCO GRF DOL ALP CUV CTG DCB DMO FRS EMR IMC JMO LVP LRG JAF MITF NPC PRKF SMRT SB SCO. Wrote the paper: JCR AS RJM GCO AM VA VD ARS FAD LGCP MZT NS TLPC JM AZ SCS SSA VACA DMR ET JB AT. Obtained permission for use of cell line: RJM RM AM VA. Bioinformatic support: JCR GCO AD FPL PG.
Descrição: Corynebacterium pseudotuberculosis, a gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity. We characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer. These particular genome characteristics of C. pseudotuberculosis, as well as its acquired virulence factors in pathogenicity islands, provide evidence of its lifestyle and of the pathogenicity pathways used by this pathogen in the infection process. All genomes cited in this study are available in the NCBI Genbank database (http://www.ncbi.nlm.nih.gov/genbank/) under accession numbers CP001809 and CP001829.
Editor: United States: Public Library of Science
Idioma: Inglês

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Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains

United States: Public Library of Science

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