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Modifying the physicochemical properties of NSAIDs for nasal and pulmonary administration

Szabó-Révész, P.

Drug discovery today. Technologies, 2018-07, Vol.27, p.87-93 [Periódico revisado por pares]

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Título:
Modifying the physicochemical properties of NSAIDs for nasal and pulmonary administration
Autor: Szabó-Révész, P.
Assuntos: Administration, Inhalation ; Administration, Intranasal ; Alzheimer Disease - prevention & control ; Analgesia ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Cystic Fibrosis - drug therapy ; Dosage Forms ; Humans ; Lung - metabolism ; Lung Neoplasms - drug therapy
É parte de: Drug discovery today. Technologies, 2018-07, Vol.27, p.87-93
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: [Display omitted] This review focuses on nasal and pulmonary delivery of NSAIDs (non-steroidal anti-inflammatory drugs) for fast-onset analgesia, for the potential prevention of Alzheimer’s disease (AD), as well as for an add-on treatment in cystic fibrosis (CF) and non-small cell lung cancer (NSCLC). I discuss how the physicochemical properties of NSAIDs can be modified with respect to the biological characteristics of the target site. Innovative technology and/or dosage forms can promote an effective therapy.
Editor: England: Elsevier Ltd
Idioma: Inglês

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