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Kinase and Phosphatase Cross-Talk at the Kinetochore

Saurin, Adrian T

Frontiers in cell and developmental biology, 2018-06, Vol.6, p.62-62 [Periódico revisado por pares]

Switzerland: Frontiers Research Foundation

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  • Título:
    Kinase and Phosphatase Cross-Talk at the Kinetochore
  • Autor: Saurin, Adrian T
  • Assuntos: Cdk1 ; Cell and Developmental Biology ; Chromosomes ; Enzymes ; kinase ; kinetochore ; Kinetochores ; phosphatase ; Phosphatases ; PP2A ; spindle assembly checkpoint
  • É parte de: Frontiers in cell and developmental biology, 2018-06, Vol.6, p.62-62
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Edited by: Sabine Elowe, Laval University, Canada
    Reviewed by: Brian Gabrielli, The University of Queensland, Australia; Andrew Burgess, Anzac Research Institute, Australia; Andrea Musacchio, Max-Planck-Institut für Molekulare Physiologie, Germany
    This article was submitted to Cell Growth and Division, a section of the journal Frontiers in Cell and Developmental Biology
  • Descrição: Multiple kinases and phosphatases act on the kinetochore to control chromosome segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown to regulate both kinetochore-microtubule attachments and the spindle assembly checkpoint. Given that so many kinases and phosphatases converge onto two key mitotic processes, it is perhaps not surprising to learn that they are, quite literally, entangled in cross-talk. Inhibition of any one of these enzymes produces secondary effects on all the others, which results in a complicated picture that is very difficult to interpret. This review aims to clarify this picture by first collating the direct effects of each enzyme into one overarching schematic of regulation at the Knl1/Mis12/Ndc80 (KMN) network (a major signaling hub at the outer kinetochore). This schematic will then be used to discuss the implications of the cross-talk that connects these enzymes; both in terms of why it may be needed to produce the right type of kinetochore signals and why it nevertheless complicates our interpretations about which enzymes control what processes. Finally, some general experimental approaches will be discussed that could help to characterize kinetochore signaling by dissociating the direct from indirect effect of kinase or phosphatase inhibition . Together, this review should provide a framework to help understand how a network of kinases and phosphatases cooperate to regulate two key mitotic processes.
  • Editor: Switzerland: Frontiers Research Foundation
  • Idioma: Inglês
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