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The presence of morphine as heroin metabolites in placental tissue and fetus: case report

Nikolic, Slobodan ; Micic-Labudovic, Jelena ; Lukic, Vera ; Zivkovic, Vladimir

Srpski arhiv za celokupno lekarstvo, 2014-09, Vol.142 (9-10), p.610-613

Serbia: Serbian Medical Society

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Título:
The presence of morphine as heroin metabolites in placental tissue and fetus: case report
Autor: Nikolic, Slobodan ; Micic-Labudovic, Jelena ; Lukic, Vera ; Zivkovic, Vladimir
Assuntos: Adult ; Autopsy ; Female ; Fetal Death ; Gas Chromatography-Mass Spectrometry ; heroin ; Heroin - analysis ; Heroin Dependence ; Humans ; Infant, Newborn ; Liver - chemistry ; Liver - embryology ; meconium ; Meconium - chemistry ; morphine ; Morphine - analysis ; Morphine - isolation & purification ; Morphine Derivatives - analysis ; Narcotics - analysis ; placenta ; Pregnancy
É parte de: Srpski arhiv za celokupno lekarstvo, 2014-09, Vol.142 (9-10), p.610-613
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Descrição: Females who have developed addiction to heroin also abuse it during pregnancy. Heroin can be detected in the fetal blood-flow already an hour after maternal i.v. injection. Heroin metabolites enter the fetal blood-flow through the placental barrier by passive transport. We present a 27-year-old female in the 5th month of pregnancy that had a miscarriage. Chemo-toxicological analysis (gas chromatography with mass spectrometry--GC/MS), showed the presence of morphine in the fetal liver (31.92 ng/g), placenta (27.94 ng/g) and meconium (136.33 ng/g). The analysis did not show the presence of 6-monoacetylmorphine. In all cases when the autopsy of fetus or newborn is performed, with mother suspected as i.v. heroin abuser, chemo- toxicological placental analysis, placenta and meconium should be also done.
Editor: Serbia: Serbian Medical Society
Idioma: Serbian;Inglês

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The presence of morphine as heroin metabolites in placental tissue and fetus: case report

Nikolic, Slobodan ; Micic-Labudovic, Jelena ; Lukic, Vera ; Zivkovic, Vladimir

Serbia: Serbian Medical Society

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