skip to main content
Idioma:

Impact of Long-Term Poor and Good Glycemic Control on Metabolomics Alterations in Type 1 Diabetic People

Dutta, Tumpa ; Kudva, Yogish C ; Persson, Xuan-Mai T ; Schenck, Louis A ; Ford, G. Charles ; Singh, Ravinder J ; Carter, Rickey ; Nair, K. Sreekumaran

The journal of clinical endocrinology and metabolism, 2016-03, Vol.101 (3), p.1023-1033 [Periódico revisado por pares]

United States: Endocrine Society

Texto completo disponível

Citações Citado por
  • Título:
    Impact of Long-Term Poor and Good Glycemic Control on Metabolomics Alterations in Type 1 Diabetic People
  • Autor: Dutta, Tumpa ; Kudva, Yogish C ; Persson, Xuan-Mai T ; Schenck, Louis A ; Ford, G. Charles ; Singh, Ravinder J ; Carter, Rickey ; Nair, K. Sreekumaran
  • Assuntos: Adult ; Amino Acids - metabolism ; Blood Glucose - analysis ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - therapy ; Fatty Acids, Nonesterified - metabolism ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Lipid Metabolism ; Male ; Metabolic Networks and Pathways ; Metabolomics ; Middle Aged ; Original ; Risk Factors ; Vitamin D - metabolism
  • É parte de: The journal of clinical endocrinology and metabolism, 2016-03, Vol.101 (3), p.1023-1033
  • Notas: This work was supported by National Institutes of Health Grants R01 DK41973, U24 DK100469, and UL1 TR000135 as well as the David Murdock Dole Professorship.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Context: Poor glycemic control in individuals with type 1 diabetes (T1D) is associated with both micro- and macrovascular complications, but good glycemic control does not fully prevent the risk of these complications. Objective: The objective of the study was to determine whether T1D with good glycemic control have persistent abnormalities of metabolites and pathways that exist in T1D with poor glycemic control. Design: We compared plasma metabolites in T1D with poor (glycated hemoglobin ≥ 8.5%, T1D[−] and good (glycated hemoglobin < 6.5%, T1D[+]) glycemic control with nondiabetic controls (ND). Setting: The study was conducted at the clinical research unit. Patients or Other Participants: T1D with poor (n = 14), T1D(−) and good, T1D(+) (n = 15) glycemic control and matched (for age, sex, and body mass index) ND participants were included in the study. Intervention(s): There were no intervention. Main Outcome Measure(s): Comparison of qualitative and quantitative profiling of metabolome was performed. Results: In T1D(−), 347 known metabolites belonging to 38 metabolic pathways involved in cholesterol, vitamin D, tRNA, amino acids (AAs), bile acids, urea, tricarboxylic acid cycle, immune response, and eicosanoids were different from ND. In T1D(+),154 known metabolites belonging to 26 pathways including glycolysis, gluconeogenesis, bile acids, tRNA biosynthesis, AAs, branch-chain AAs, retinol, and vitamin D metabolism remained altered from ND. Targeted measurements of AA metabolites, trichloroacetic acid, and free fatty acids showed directional changes similar to the untargeted metabolomics approach. Conclusions: Comprehensive metabolomic profiling identified extensive metabolomic abnormalities in T1D with poor glycemic control. Chronic good glycemic control failed to normalize many of these perturbations, suggesting a potential role for these persistent abnormalities in many complications in T1D.
  • Editor: United States: Endocrine Society
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.