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Enhancement of therapeutic efficacy of aclarubicin against lymph node metastases using a new dosage form: aclarubicin adsorbed on activated carbon particles

Sakakura, Chouhei ; Takahashi, Toshio ; Sawai, Kiyoshi ; Hagiwara, Akeo ; Ito, Michitoshi ; Shobayashi, Satoshi ; Sasaki, Sadayuki ; Ozaki, Kimihiko ; Shirasu, Morio

Anti-cancer drugs, 1992-06, Vol.3 (3), p.233-236 [Periódico revisado por pares]

LONDON: Lippincott-Raven Publishers

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Título:
Enhancement of therapeutic efficacy of aclarubicin against lymph node metastases using a new dosage form: aclarubicin adsorbed on activated carbon particles
Autor: Sakakura, Chouhei ; Takahashi, Toshio ; Sawai, Kiyoshi ; Hagiwara, Akeo ; Ito, Michitoshi ; Shobayashi, Satoshi ; Sasaki, Sadayuki ; Ozaki, Kimihiko ; Shirasu, Morio
Assuntos: Aclarubicin - administration & dosage ; Aclarubicin - pharmacokinetics ; Aclarubicin - therapeutic use ; Animals ; Charcoal ; Leukemia P388 - complications ; Leukemia P388 - drug therapy ; Life Sciences & Biomedicine ; Lymph Nodes - pathology ; Lymphatic Metastasis - pathology ; Lymphatic Metastasis - prevention & control ; Male ; Mice ; Mice, Inbred Strains ; Oncology ; Pharmacology & Pharmacy ; Science & Technology
É parte de: Anti-cancer drugs, 1992-06, Vol.3 (3), p.233-236
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Seven days after a subcutaneous inoculation of 5 × 10 P388 leukemia cells Into the foot pad of the left hind paw of donor mouse, aclarubicin (0.2 mg/kg body weight) was injected subcutaneously Into the hind paw of the opposite foot pad in the form of ACR-CH or aclarubicin aqueous solution. On day 10, the left popliteal and the lower para-aortic lymph nodes taken from each donor were transferred Intraperltoneally to a normal recipient mouse. The combined survival time of recipients and the viable P388 leukemia cell number In popliteal and para-aortic lymph nodes were estimated with a calibration formula. Our results showed that the survival curve of recipients given ACR-CH was statistically improved compared with that of other treatment groups.
Editor: LONDON: Lippincott-Raven Publishers
Idioma: Inglês

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Enhancement of therapeutic efficacy of aclarubicin against lymph node metastases using a new dosage form: aclarubicin adsorbed on activated carbon particles

Sakakura, Chouhei ; Takahashi, Toshio ; Sawai, Kiyoshi ; Hagiwara, Akeo ; Ito, Michitoshi ; Shobayashi, Satoshi ; Sasaki, Sadayuki ; Ozaki, Kimihiko ; Shirasu, Morio

LONDON: Lippincott-Raven Publishers

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