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Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

Deseyve, Catarina ; Domingues, Ana Verónica ; Carvalho, Tawan T. A. ; Armada, Gisela ; Correia, Raquel ; Vieitas‐Gaspar, Natacha ; Wezik, Marcelina ; Pinto, Luísa ; Sousa, Nuno ; Coimbra, Bárbara ; Rodrigues, Ana João ; Soares‐Cunha, Carina

Journal of neurochemistry, 2024-03, Vol.168 (3), p.312-327 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning
Autor: Deseyve, Catarina ; Domingues, Ana Verónica ; Carvalho, Tawan T. A. ; Armada, Gisela ; Correia, Raquel ; Vieitas‐Gaspar, Natacha ; Wezik, Marcelina ; Pinto, Luísa ; Sousa, Nuno ; Coimbra, Bárbara ; Rodrigues, Ana João ; Soares‐Cunha, Carina
Assuntos: Animals ; Associative learning ; Aversion ; Avoidance Learning - physiology ; Classical conditioning ; Conditioned stimulus ; Conditioning ; Conditioning, Classical ; D1‐neurons ; D2‐neurons ; Dopamine ; Dopamine D1 receptors ; Dopamine D2 receptors ; Footshock ; Learning ; Mice ; Neurons ; Neurons - metabolism ; Nucleus accumbens ; Nucleus Accumbens - metabolism ; Pavlovian conditioning ; Photometry ; Population studies ; Receptors, Dopamine D1 - metabolism ; reward ; Spiny neurons ; Sucrose ; Sucrose - pharmacology ; Unconditioned stimulus ; γ-Aminobutyric acid
É parte de: Journal of neurochemistry, 2024-03, Vol.168 (3), p.312-327
Notas: Catarina Deseyve, Ana Verónica Domingues and Tawan T. A. Carvalho contributed equally to this work.
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Descrição: To survive, individuals must learn to associate cues in the environment with emotionally relevant outcomes. This association is partially mediated by the nucleus accumbens (NAc), a key brain region of the reward circuit that is mainly composed by GABAergic medium spiny neurons (MSNs), that express either dopamine receptor D1 or D2. Recent studies showed that both populations can drive reward and aversion, however, the activity of these neurons during appetitive and aversive Pavlovian conditioning remains to be determined. Here, we investigated the relevance of D1‐ and D2‐neurons in associative learning, by measuring calcium transients with fiber photometry during appetitive and aversive Pavlovian tasks in mice. Sucrose was used as a positive valence unconditioned stimulus (US) and foot shock was used as a negative valence US. We show that during appetitive Pavlovian conditioning, D1‐ and D2‐neurons exhibit a general increase in activity in response to the conditioned stimuli (CS). Interestingly, D1‐ and D2‐neurons present distinct changes in activity after sucrose consumption that dynamically evolve throughout learning. During the aversive Pavlovian conditioning, D1‐ and D2‐neurons present an increase in the activity in response to the CS and to the US (shock). Our data support a model in which D1‐ and D2‐neurons are concurrently activated during appetitive and aversive conditioning. We examined the involvement of nucleus accumbens' D1‐ and D2‐neurons in associative learning, by measuring calcium transients with fiber photometry in mice. We show that during appetitive Pavlovian learning, D1‐ and D2‐neurons exhibit a general increase in activity in response to the conditioned stimuli (CS), and distinct changes in activity after unconditioned stimulus (US – sucrose) consumption that dynamically evolve throughout learning. In an aversive Pavlovian learning task, D1‐ and D2‐neurons develop increases in activity in response to both CS and US (shock). Our data support a model of concurrent activation of D1‐ and D2‐neurons during appetitive and aversive conditioning.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

Deseyve, Catarina ; Domingues, Ana Verónica ; Carvalho, Tawan T. A. ; Armada, Gisela ; Correia, Raquel ; Vieitas‐Gaspar, Natacha ; Wezik, Marcelina ; Pinto, Luísa ; Sousa, Nuno ; Coimbra, Bárbara ; Rodrigues, Ana João ; Soares‐Cunha, Carina

England: Blackwell Publishing Ltd

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