Idioma:

Exposure to heterocyclic amines

Wakabayashi, K ; Ushiyama, H ; Takahashi, M ; Nukaya, H ; Kim, S.B ; Hirose, M ; Ochiai, M ; Sugimura, T ; Nagao, M

Environmental health perspectives, 1993-03, Vol.99, p.129-134 [Periódico revisado por pares]

United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare

Texto completo disponível

Citações Citado por

Enviar para

Título:
Exposure to heterocyclic amines
Autor: Wakabayashi, K ; Ushiyama, H ; Takahashi, M ; Nukaya, H ; Kim, S.B ; Hirose, M ; Ochiai, M ; Sugimura, T ; Nagao, M
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; ALIMENTOS ; AMINAS ; AMINE ; AMINES ; Amines - adverse effects ; Amines - analysis ; Amines - urine ; ANALISIS CUANTITATIVO ; ANALYSE QUANTITATIVE ; Animals ; Assessment of Carcinogen Exposure and the Use of Other Risk Markers in Populations ; Carcinogenesis ; Carcinogens ; Carcinogens - analysis ; Cigarette smoking ; COMPOSE HETEROCYCLIQUE ; COMPOSE ORGANOAZOTE ; COMPUESTO ORGANICO DEL NITROGENO ; COMPUESTOS HETEROCICLICOS ; COOKED FOODS ; Cooking ; Female ; Food Contamination - analysis ; FOODS ; GENERO HUMANO ; GENRE HUMAIN ; HETEROCYCLIC COMPOUNDS ; Heterocyclic Compounds - adverse effects ; Heterocyclic Compounds - analysis ; Heterocyclic Compounds - urine ; Humans ; Imidazoles - analysis ; Liver ; Male ; MAN ; MANKIND ; Meats ; Middle Aged ; Mutagens - analysis ; ORGANIC NITROGEN COMPOUNDS ; ORINA ; PRODUIT ALIMENTAIRE ; QUANTITATIVE ANALYSIS ; Quinoxalines - analysis ; URINE ; Volunteerism
É parte de: Environmental health perspectives, 1993-03, Vol.99, p.129-134
Notas: Q03
9420166
Descrição: Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) was highest (0.56-69.2 ng/g), that of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was second highest (0.64-6.44 ng/g), and those of other HAs were 0.03-2.50 ng/g. Heterocyclic amines were found in urine samples of 10 healthy volunteers consuming a normal diet, but HAs were not detectable in urine samples of three patients receiving parenteral alimentation. These results strongly suggest that humans are continuously exposed to HAs derived from food in the normal diet. Based on quantitative data on the levels of HAs in cooked foods and urine samples, the daily exposures to PhIP and MeIQx were estimated to be 0.1-13.8 μg and 0.2-2.6 μg per person, respectively. These levels of carcinogenic HAs are in the same range as those of other carcinogens such as N-nitrosodimethylamine and benzo[a]pyrene to which humans are exposed.
Editor: United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Exposure to heterocyclic amines

Wakabayashi, K ; Ushiyama, H ; Takahashi, M ; Nukaya, H ; Kim, S.B ; Hirose, M ; Ochiai, M ; Sugimura, T ; Nagao, M

United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare

Buscando em bases de dados remotas. Favor aguardar.