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Evidence for Gender-Specific Endophenotypes in High-Functioning Autism Spectrum Disorder During Empathy

Schneider, Karla ; Regenbogen, Christina ; Pauly, Katharina D. ; Gossen, Anna ; Schneider, Daniel A. ; Mevissen, Lea ; Michel, Tanja M. ; Gur, Ruben C. ; Habel, Ute ; Schneider, Frank

Autism research, 2013-12, Vol.6 (6), p.506-521 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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  • Título:
    Evidence for Gender-Specific Endophenotypes in High-Functioning Autism Spectrum Disorder During Empathy
  • Autor: Schneider, Karla ; Regenbogen, Christina ; Pauly, Katharina D. ; Gossen, Anna ; Schneider, Daniel A. ; Mevissen, Lea ; Michel, Tanja M. ; Gur, Ruben C. ; Habel, Ute ; Schneider, Frank
  • Assuntos: Adolescent ; Adult ; autism ; Child Development Disorders, Pervasive - genetics ; Child Development Disorders, Pervasive - physiopathology ; Child Development Disorders, Pervasive - psychology ; empathy ; Empathy - physiology ; Endophenotypes ; Female ; fMRI ; Frontal Lobe - physiopathology ; gender differences ; Humans ; Interpersonal Relations ; Magnetic Resonance Imaging - methods ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Neuropsychological Tests - statistics & numerical data ; Psychiatric Status Rating Scales - statistics & numerical data ; Sex Factors ; Social Behavior ; social interactions ; Young Adult
  • É parte de: Autism research, 2013-12, Vol.6 (6), p.506-521
  • Notas: German Research Foundation - No. KFO 112; No. HA 3202/7-1
    Figure S1. Watching Emotional vs. Neutral Video Clips: activation in healthy subjects (green) and ASD patients (red); flexible-factorial analysis (P < 0.05 Family Wise Error corrected, extent threshold = 20 voxels). Table S1. Demographical and neuropsychological data for autistic patients and healthy control subjects separated for gender. Table S2. Additional neuropsychological data for autistic patients separated for gender. Table S3. Brain activations when watching emotional vs. neutral video clips (E>N contrast) in healthy control subjects (Con) and ASD patients (ASD)-One-sample analyses.
    Interdisciplinary Center for Clinical Research of the Medical Faculty of the RWTH Aachen University - No. IZKF, N2-6
    ark:/67375/WNG-7GKW47X4-G
    ArticleID:AUR1310
    istex:F65030B5A699268D50B9DC1DFF5D298B3540EA8F
    Grant sponsors
    Grant Number: KFO 112 and HA 3202/7‐1
    1. Grant sponsor: German Research Foundation (DFG, International Research Training Group 1328: “Brain‐behavior relationship of emotion and social cognition in schizophrenia and autism”)
    2. Grant sponsor: Interdisciplinary Center for Clinical Research of the Medical Faculty of the RWTH Aachen University
    Grant number: IZKF, N2‐6
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Despite remarkable behavioral gender differences in patients with autism spectrum disorder (ASD), and growing evidence for a diminished male : female ratio for the putative “male disorder” ASD, aspects of gender are not addressed accordingly in ASD research. Our study aims at filling this gap by exploring empathy abilities in a group of 28 patients with high‐functioning ASD and 28 gender‐, age‐ and education‐matched non‐autistic subjects, for the first time by means of functional neuroimaging (fMRI). In an event‐related fMRI paradigm, emotional (“E”) and neutral (“N”) video clips presented actors telling self‐related short stories. After each clip, participants were asked to indicate their own emotion and its intensity as well as the emotion and intensity perceived for the actor. Behaviorally, we found significantly less empathic responses in the overall ASD group compared with non‐autistic subjects, and inadequate emotion recognition for the neutral clips in the female ASD group compared with healthy women. Neurally, increased activation of the bilateral medial frontal gyrus was found in male patients compared with female patients, a pattern which was not present in the non‐autistic group. Additionally, autistic women exhibited decreased activation of midbrain and limbic regions compared with non‐autistic women, whereas there was no significant difference within the male group. While we did not find a fundamental empathic deficit in autistic patients, our data propose different ways of processing empathy in autistic men and women, suggesting stronger impairments in cognitive aspects of empathy/theory of mind for men, and alterations of social reciprocity for women. Autism Res 2013, 6: 506–521. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.
  • Editor: United States: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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