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Progress in miRNA Detection Using Graphene Material–Based Biosensors

Zhang, Congcong ; Miao, Pei ; Sun, Mingyuan ; Yan, Mei ; Liu, Hong

Small (Weinheim an der Bergstrasse, Germany), 2019-09, Vol.15 (38), p.e1901867-n/a [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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  • Título:
    Progress in miRNA Detection Using Graphene Material–Based Biosensors
  • Autor: Zhang, Congcong ; Miao, Pei ; Sun, Mingyuan ; Yan, Mei ; Liu, Hong
  • Assuntos: Biomarkers ; Biosensors ; electrochemical biosensors ; Graphene ; graphene and its derivatives ; Medical research ; MicroRNAs ; miRNA detection ; Nanotechnology ; optical biosensors ; Optical properties ; Organic chemistry ; Sensors ; supramolecular nanoassemblies
  • É parte de: Small (Weinheim an der Bergstrasse, Germany), 2019-09, Vol.15 (38), p.e1901867-n/a
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs that play critical roles in physiologic and pathologic processes and are vital biomarkers for several disease diagnostics and therapeutics. Therefore, rapid, low‐cost, sensitive, and selective detection of miRNAs is of paramount importance and has aroused increasing attention in the field of medical research. Among the various reported miRNA sensors, devices based on graphene and its derivatives, which form functional supramolecular nanoassemblies of π‐conjugated molecules, have been revealed to have great potential due to their extraordinary electrical, chemical, optical, mechanical, and structural properties. This Review critically and comprehensively summarizes the recent progress in miRNA detection based on graphene and its derivative materials, with an emphasis on i) the underlying working principles of these types of sensors, and the unique roles and advantages of graphene materials; ii) state‐of‐the‐art protocols recently developed for high‐performance miRNA sensing, including representative examples; and iii) perspectives and current challenges for graphene sensors. This Review intends to provide readers with a deep understanding of the design and future of miRNA detection devices. MicroRNA (MiRNA) detection based on graphene materials, in which the excellent stability, electrical conductivity, unique physical/chemical properties, and good biocompatibility of graphene materials are integrated in a single device, have aroused great attention from scientific and technological communities. This Review highlights recent progresses in this field with electrochemical and fluorescence detection methods, the state‐of‐the‐art protocols developed for high‐performance miRNA sensing.
  • Editor: Germany: Wiley Subscription Services, Inc
  • Idioma: Inglês
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