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Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, Erin L ; Simpson, Eric L ; Fredrikson, Lorna J ; Lee, James J ; Lee, Nancy A ; Fryer, Allison D ; Jacoby, David B Tsokos, George C.

PloS one, 2011-07, Vol.6 (7), p.e22029-e22029 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Eosinophils increase neuron branching in human and murine skin and in vitro
Autor: Foster, Erin L ; Simpson, Eric L ; Fredrikson, Lorna J ; Lee, James J ; Lee, Nancy A ; Fryer, Allison D ; Jacoby, David B
Tsokos, George C.
Assuntos: Animals ; Antigens ; Asthma ; Atopic dermatitis ; Biochemistry ; Biology ; Biopsy ; Brain-derived neurotrophic factor ; Cell activation ; Cell Communication ; Cell Count ; Cell culture ; Cell Survival ; Chemokine CCL11 - metabolism ; Chemokines ; Critical care ; Cytokines ; Dermatitis ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - pathology ; Dermis - immunology ; Dermis - innervation ; Dermis - pathology ; Diabetes ; Diabetic neuropathy ; Dorsal root ganglia ; Eczema ; Eosinophil Granule Proteins - metabolism ; Eosinophil Peroxidase - metabolism ; Eosinophils ; Eosinophils - cytology ; Eosinophils - immunology ; Eotaxin ; Epidermis ; Epidermis - immunology ; Epidermis - innervation ; Epidermis - pathology ; Ganglia ; Ganglia, Spinal - metabolism ; Genetic engineering ; Health ; Health aspects ; Humans ; Intercellular adhesion molecule 1 ; Intercellular Adhesion Molecule-1 - metabolism ; Interleukin ; Interleukin 5 ; Interleukin-5 - metabolism ; Interleukins ; Keratin ; Keratinocytes - metabolism ; Kinases ; Leukocytes (eosinophilic) ; Mast cells ; Mast Cells - cytology ; Mast Cells - immunology ; Medicine ; Mice ; Mice, Transgenic ; Morphology ; Nerve growth factor ; Nerve Growth Factors - antagonists & inhibitors ; Nerve Growth Factors - metabolism ; Nerves ; Neurites - metabolism ; Neurons ; Pathogenesis ; Patients ; Proteins ; Rodents ; Sensory neurons ; Sensory Receptor Cells - immunology ; Sensory Receptor Cells - metabolism ; Skin ; Skin - enzymology ; Skin - immunology ; Skin - innervation ; Skin - pathology ; Skin diseases ; Transgenic animals ; Transgenic mice ; Vascular cell adhesion molecule 1 ; Vascular Cell Adhesion Molecule-1 - metabolism
É parte de: PloS one, 2011-07, Vol.6 (7), p.e22029-e22029
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Conceived and designed the experiments: EF LF NL JL AF DJ. Performed the experiments: EF ES LF NL. Analyzed the data: EF AF DJ. Contributed reagents/materials/analysis tools: ES LF NL JL. Wrote the paper: ES NL DJ.
Descrição: Cutaneous nerves are increased in atopic dermatitis, and itch is a prominent symptom. We studied the functional interactions between eosinophils and nerves in human and mouse skin and in culture. We demonstrated that human atopic dermatitis skin has eosinophil granule proteins present in the same region as increased nerves. Transgenic mice in which interleukin-5 (IL-5) expression is driven by a keratin-14 (K14) promoter had many eosinophils in the epidermis, and the number of nerves was also significantly increased in the epidermis. In co-cultures, eosinophils dramatically increased branching of sensory neurons isolated from the dorsal root ganglia (DRG) of mice. This effect did not occur in DRG neurons co-cultured with mast cells or with dead eosinophils. Physical contact of the eosinophils with the neurons was not required, and the effect was not blocked by an antibody to nerve growth factor. DRG neurons express eotaxin-1, ICAM-1 and VCAM-1, which may be important in the recruitment, binding, and activation of eosinophils in the region of cutaneous nerves. These data indicate a pathophysiological role for eosinophils in cutaneous nerve growth in atopic dermatitis, and suggest they may present a therapeutic target in atopic dermatitis and other eosinophilic skin conditions with neuronal symptoms such as itch.
Editor: United States: Public Library of Science
Idioma: Inglês

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Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, Erin L ; Simpson, Eric L ; Fredrikson, Lorna J ; Lee, James J ; Lee, Nancy A ; Fryer, Allison D ; Jacoby, David B Tsokos, George C.

United States: Public Library of Science

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