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Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries

Metzger, Monika L ; Howard, Scott C ; Fu, Ligia C ; Peña, Armando ; Stefan, Rene ; Hancock, Michael L ; Zhang, Zhe ; Pui, Ching-Hon ; Wilimas, Judy ; Ribeiro, Raul C

The Lancet (British edition), 2003-08, Vol.362 (9385), p.706-708 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries
Autor: Metzger, Monika L ; Howard, Scott C ; Fu, Ligia C ; Peña, Armando ; Stefan, Rene ; Hancock, Michael L ; Zhang, Zhe ; Pui, Ching-Hon ; Wilimas, Judy ; Ribeiro, Raul C
Assuntos: Adolescent ; Child ; Child, Preschool ; Developing Countries - economics ; Developing Countries - statistics & numerical data ; Female ; Health Services Accessibility - standards ; Health Services Accessibility - statistics & numerical data ; Honduras ; Humans ; Infant ; Male ; Medically Underserved Area ; Patient Dropouts - statistics & numerical data ; Poverty - statistics & numerical data ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Risk Factors ; Treatment Failure
É parte de: The Lancet (British edition), 2003-08, Vol.362 (9385), p.706-708
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The causes of treatment failure in childhood acute lymphoblastic leukaemia are thought to differ between resource-rich and resource-poor countries. We assessed the records of 168 patients treated for this disease in Honduras. Abandonment of treatment (n=38), the main cause of failure, was associated with prolonged travel time to the treatment facility (2–5 h: hazard ratio 3·1, 95% CI 1·2–8·1 vs >5 h: 3·7, 1·3–10·9) and age younger than 4·5 years (2·6, 1·1–6·3). 35 patients died of treatment-related effects. Outcome could be substantially improved by interventions that help to prevent abandonment of therapy (such as funding for transport, satellite clinics, and support groups), and by prompt treatment of infection.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries

Metzger, Monika L ; Howard, Scott C ; Fu, Ligia C ; Peña, Armando ; Stefan, Rene ; Hancock, Michael L ; Zhang, Zhe ; Pui, Ching-Hon ; Wilimas, Judy ; Ribeiro, Raul C

England: Elsevier Ltd

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