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A Phase II Study of Plerixafor (AMD3100) plus G-CSF for Autologous Hematopoietic Progenitor Cell Mobilization in Patients with Hodgkin Lymphoma

Cashen, Amanda ; Lopez, Sandra ; Gao, Feng ; Calandra, Gary ; MacFarland, Ron ; Badel, Karin ; DiPersio, John

Biology of blood and marrow transplantation, 2008-11, Vol.14 (11), p.1253-1261

United States: Elsevier Inc

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Título:
A Phase II Study of Plerixafor (AMD3100) plus G-CSF for Autologous Hematopoietic Progenitor Cell Mobilization in Patients with Hodgkin Lymphoma
Autor: Cashen, Amanda ; Lopez, Sandra ; Gao, Feng ; Calandra, Gary ; MacFarland, Ron ; Badel, Karin ; DiPersio, John
Assuntos: Adolescent ; Adult ; Aged ; AMD3100 ; Anti-HIV Agents - administration & dosage ; Anti-HIV Agents - pharmacokinetics ; Antigens, CD34 ; Blood Component Removal ; Female ; Granulocyte Colony-Stimulating Factor - administration & dosage ; Granulocyte Colony-Stimulating Factor - pharmacokinetics ; Hematology, Oncology and Palliative Medicine ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Stem Cells ; Heterocyclic Compounds - administration & dosage ; Heterocyclic Compounds - pharmacokinetics ; Hodgkin Disease - therapy ; Hodgkin lymphoma ; Humans ; Male ; Middle Aged ; Plerixafor ; Stem Cell Transplantation ; Transplantation, Autologous
É parte de: Biology of blood and marrow transplantation, 2008-11, Vol.14 (11), p.1253-1261
Descrição: Collection of an adequate number of hematopoietic stem cells can be difficult in patients with relapsed or refractory Hodgkin lymphoma (HL) who are candidates for autologous stem cell transplantation (ASCT). Plerixafor (AMD3100), an inhibitor of the interaction between stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4, is an effective hematopoietic stem cell mobilization agent in patients with multiple myeloma and non-Hodgkin lymphoma (NHL). This study was undertaken to investigate the efficacy and safety of hematopoietic stem cell mobilization with plerixafor in patients with HL. Twenty-two patients with HL who were candidates for ASCT underwent hematopoietic stem cell mobilization with a combination of granulocyle-colony stimulating factor (G-CSF), 10 μg/kg daily, and plerixafor, 240 μg/kg subcutaneous, 10-11 hours prior to apheresis. The primary endpoint was the proportion of patients who collected ≥5 × 106 CD34+ cells/kg. Outcomes were compared to a historical control population of HL patients mobilized with G-CSF alone. Pharmacokinetic (PK) analysis of plerixafor was performed in a subset of patients. Fifteen patients (68%) collected ≥5 × 106 CD34+ cells/kg, and 21 patients (95%) achieved the minimum collection of ≥2 × 106 CD34+ cells/kg, in a median 2 apheresis procedures. Both the proportion of patients collecting ≥5 × 106 CD34+ cells/kg and the median CD34+ cells collected in days 1-2 of apheresis were significantly improved over historical controls. The PK of plerixafor in this patient population was similar to that previously seen in healthy volunteers. The regimen was generally safe and well tolerated.
Editor: United States: Elsevier Inc
Idioma: Inglês

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A Phase II Study of Plerixafor (AMD3100) plus G-CSF for Autologous Hematopoietic Progenitor Cell Mobilization in Patients with Hodgkin Lymphoma

Cashen, Amanda ; Lopez, Sandra ; Gao, Feng ; Calandra, Gary ; MacFarland, Ron ; Badel, Karin ; DiPersio, John

United States: Elsevier Inc

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