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Complexation induced fluorescence and acid-base properties of dapoxyl dye with γ-cyclodextrin: a drug-binding application using displacement assays

Pal, Kaushik ; Mallick, Suman ; Koner, Apurba L

Physical chemistry chemical physics : PCCP, 2015-06, Vol.17 (24), p.16015-16022 [Periódico revisado por pares]

England

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Título:
Complexation induced fluorescence and acid-base properties of dapoxyl dye with γ-cyclodextrin: a drug-binding application using displacement assays
Autor: Pal, Kaushik ; Mallick, Suman ; Koner, Apurba L
Assuntos: Acetaminophen - chemistry ; Ampicillin - chemistry ; Aspirin - chemistry ; beta-Cyclodextrins - chemistry ; Binding Sites ; Chloramphenicol - chemistry ; Drug Delivery Systems ; Fluorescence ; Fluorescent Dyes - chemistry ; Fluorometry ; Hydrogen-Ion Concentration ; Ibuprofen - chemistry ; Kanamycin - chemistry ; Oxazines - chemistry ; Oxazoles - chemistry ; Piroxicam - chemistry ; Salicylates - chemistry ; Salicylic Acid - chemistry ; Sorbic Acid - chemistry ; Sulfonamides - chemistry ; Thiamphenicol - chemistry ; Xanthenes - chemistry
É parte de: Physical chemistry chemical physics : PCCP, 2015-06, Vol.17 (24), p.16015-16022
Descrição: Host-guest complexation of dapoxyl sodium sulphonate (DSS), an intramolecular charge transfer dye with water-soluble and non-toxic macrocycle γ-cyclodextrin (γ-CD), has been investigated in a wide pH range. Steady-state absorption, fluorescence and time-resolved fluorescence measurements confirm the positioning of DSS into the hydrophobic cavity of γ-CD. A large fluorescence enhancement ca. 30 times, due to 1 : 2 complex formation and host-assisted guest-protonation have been utilised for developing a method for the utilisation of CD based drug-delivery applications. A simple fluorescence-displacement based approach is implemented at physiological pH for the assessment of binding strength of pharmaceutically useful small drug molecules (ibuprofen, paracetamol, methyl salicylate, salicylic acid, aspirin, and piroxicam) and six important antibiotic drugs (resazurin, thiamphenicol, chloramphenicol, ampicillin, kanamycin, and sorbic acid) with γ-CD.
Editor: England
Idioma: Inglês

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Complexation induced fluorescence and acid-base properties of dapoxyl dye with γ-cyclodextrin: a drug-binding application using displacement assays

Pal, Kaushik ; Mallick, Suman ; Koner, Apurba L

England

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