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Prevalence of endosalpingiosis and other benign gynecologic lesions

Sunde, Jan ; Wasickanin, Morgan ; Katz, Tiffany A ; Wickersham, Emily L ; Steed, D O Emilie ; Simper, Novae Matsuzaki, Sachiko

PloS one, 2020-05, Vol.15 (5), p.e0232487-e0232487 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Prevalence of endosalpingiosis and other benign gynecologic lesions
Autor: Sunde, Jan ; Wasickanin, Morgan ; Katz, Tiffany A ; Wickersham, Emily L ; Steed, D O Emilie ; Simper, Novae
Matsuzaki, Sachiko
Assuntos: Adnexal diseases ; Adnexal Diseases - epidemiology ; Adnexal Diseases - pathology ; Adnexitis ; Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Benign ; Biology and Life Sciences ; Cancer ; Child ; Choristoma - epidemiology ; Choristoma - pathology ; Clinical trials ; Cysts ; Demographic aspects ; Diagnosis ; Diseases ; Endometriosis ; Endometriosis - epidemiology ; Endometriosis - pathology ; Fallopian Tube Diseases - epidemiology ; Fallopian Tube Diseases - pathology ; Fallopian Tubes - pathology ; Female ; Genital Diseases, Female - epidemiology ; Genital Diseases, Female - pathology ; Genital Neoplasms, Female - epidemiology ; Genital Neoplasms, Female - pathology ; Gynecology ; Health risks ; Humans ; Implantation ; Lesions ; Malignancy ; Medicine and Health Sciences ; Menopause ; Middle Aged ; Nests ; Obstetrics ; Ovarian cancer ; Pathology ; Patients ; Prevalence ; Retrospective Studies ; Risk factors ; Sectioning ; Statistical analysis ; Surgery ; Tumors ; Young Adult
É parte de: PloS one, 2020-05, Vol.15 (5), p.e0232487-e0232487
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors do not have conflicts of interest to report. Several authors are members of the armed forces. The views expressed are those of the author(s) and do not reflect the official policy of the Department of the Army, the Department of Defense of the US government. The investigators have adhered to the policies for protection of human subjects as prescribed in 45 CFR 46.
Descrição: Endosalpingiosis, traditionally regarded as an incidental pathological finding, was recently reported to have an association with gynecologic malignancies. To determine the prevalence of endosalpingiosis, we evaluated all benign appearing adnexal lesions using the Sectioning and Extensively Examining-Fimbria (SEE-Fim) protocol, and queried the pathology database for the presence of endosalpingiosis, gynecologic malignancy, endometriosis, Walthard nests, and paratubal cysts. Using the SEE-Fim protocol, the prevalence of endosalpingiosis, endometriosis, Walthard nests, and paratubal cysts were 22%, 45%, 33%, and 42% respectively, substantially higher than previously reported. All lesions were observed to increase with age except endometriosis which increased until menopause then decreased dramatically. Among specimens including ovarian tissue, the prevalence of implantation of at least one lesion type was ubiquitous in patients age 51 and older (93%). The clinical significance of endosalpingiosis should be a continued area of research with larger trials assessing prevalence, factors affecting incidence, and association with malignancy. Our findings contribute to elucidating the origin of ectopic lesions and gynecologic disease risk.
Editor: United States: Public Library of Science
Idioma: Inglês

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Prevalence of endosalpingiosis and other benign gynecologic lesions

Sunde, Jan ; Wasickanin, Morgan ; Katz, Tiffany A ; Wickersham, Emily L ; Steed, D O Emilie ; Simper, Novae Matsuzaki, Sachiko

United States: Public Library of Science

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