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Cynomolgus macaque as an animal model for severe acute respiratory syndrome

Lawler, James V ; Endy, Timothy P ; Hensley, Lisa E ; Garrison, Aura ; Fritz, Elizabeth A ; Lesar, May ; Baric, Ralph S ; Kulesh, David A ; Norwood, David A ; Wasieloski, Leonard P ; Ulrich, Melanie P ; Slezak, Tom R ; Vitalis, Elizabeth ; Huggins, John W ; Jahrling, Peter B ; Paragas, Jason Peiris, Joseph S. M.

PLoS medicine, 2006-05, Vol.3 (5), p.e149-e149 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Cynomolgus macaque as an animal model for severe acute respiratory syndrome
Autor: Lawler, James V ; Endy, Timothy P ; Hensley, Lisa E ; Garrison, Aura ; Fritz, Elizabeth A ; Lesar, May ; Baric, Ralph S ; Kulesh, David A ; Norwood, David A ; Wasieloski, Leonard P ; Ulrich, Melanie P ; Slezak, Tom R ; Vitalis, Elizabeth ; Huggins, John W ; Jahrling, Peter B ; Paragas, Jason
Peiris, Joseph S. M.
Assuntos: Adults ; animal models of infection ; Animals ; antibodies ; Antibody Formation ; BASIC BIOLOGICAL SCIENCES ; Child, Preschool ; Cloning ; Coronaviruses ; Disease Models, Animal ; Disease transmission ; Diseases ; Epidemics ; Female ; Humans ; Illnesses ; Infections ; Infectious Diseases ; Macaca fascicularis - virology ; macaque ; Macaques ; Male ; Medical Imaging ; Microbiology ; Monkeys & apes ; Mucous Membrane - virology ; Pathogenesis ; Pneumonia ; Public domain ; Respiratory diseases ; Respiratory distress syndrome ; respiratory infections ; SARS ; SARS coronavirus ; SARS Virus - pathogenicity ; SARS Virus - physiology ; Severe acute respiratory syndrome ; Severe Acute Respiratory Syndrome - drug therapy ; Severe Acute Respiratory Syndrome - immunology ; Severe Acute Respiratory Syndrome - physiopathology ; Severe Acute Respiratory Syndrome - prevention & control ; Severity of Illness Index ; Syndrome ; Vaccines ; viral replication ; Virology ; Virus Replication
É parte de: PLoS medicine, 2006-05, Vol.3 (5), p.e149-e149
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
AC52-07NA27344; AI059136
Department of the Army
National Institute of Allergy and Infectious Diseases (NIAID)
National Institutes of Health (NIH)
USDOE Office of Science (SC), Biological and Environmental Research (BER)
a Current address: Division of Medicine, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, United States of America
Competing Interests: The authors have declared that no competing interests exist.
b Current address: Communicable Diseases and Immunology Division, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
c Current address: National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Maryland, United States of America
Descrição: The emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV) infection and to develop effective vaccines and therapeutics. We report the first findings of measurable clinical disease in nonhuman primates (NHPs) infected with SARS-CoV. In order to characterize clinically relevant parameters of SARS-CoV infection in NHPs, we infected cynomolgus macaques with SARS-CoV in three groups: Group I was infected in the nares and bronchus, group II in the nares and conjunctiva, and group III intravenously. Nonhuman primates in groups I and II developed mild to moderate symptomatic illness. All NHPs demonstrated evidence of viral replication and developed neutralizing antibodies. Chest radiographs from several animals in groups I and II revealed unifocal or multifocal pneumonia that peaked between days 8 and 10 postinfection. Clinical laboratory tests were not significantly changed. Overall, inoculation by a mucosal route produced more prominent disease than did intravenous inoculation. Half of the group I animals were infected with a recombinant infectious clone SARS-CoV derived from the SARS-CoV Urbani strain. This infectious clone produced disease indistinguishable from wild-type Urbani strain. SARS-CoV infection of cynomolgus macaques did not reproduce the severe illness seen in the majority of adult human cases of SARS; however, our results suggest similarities to the milder syndrome of SARS-CoV infection characteristically seen in young children.
Editor: United States: Public Library of Science
Idioma: Inglês

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Cynomolgus macaque as an animal model for severe acute respiratory syndrome

United States: Public Library of Science

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