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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Mittrücker, Hans-Willi ; Matsuyama, Toshifumi ; Grossman, Alex ; Kündig, Thomas M. ; Potter, Julia ; Shahinian, Arda ; Wakeham, Andrew ; Patterson, Bruce ; Ohashi, Pamela S. ; Mak, Tak W.

Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5299), p.540-543 [Periódico revisado por pares]

Washington, DC: American Society for the Advancement of Science

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Título:
Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
Autor: Mittrücker, Hans-Willi ; Matsuyama, Toshifumi ; Grossman, Alex ; Kündig, Thomas M. ; Potter, Julia ; Shahinian, Arda ; Wakeham, Andrew ; Patterson, Bruce ; Ohashi, Pamela S. ; Mak, Tak W.
Assuntos: Animals ; Antigen Presentation ; B lymphocytes ; B-Lymphocytes - immunology ; Biological and medical sciences ; Bone Marrow Cells ; Cell lines ; Cellular biology ; Cytotoxicity, Immunologic ; DNA ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Targeting ; Genetic regulation ; Genetic transcription ; Graft vs Host Reaction ; Immunization ; Immunobiology ; Immunoglobulins - blood ; Interferon Regulatory Factors ; Lymph nodes ; Lymphatic Diseases - etiology ; Lymphatic system ; Lymphocyte Activation ; Lymphocyte Subsets - cytology ; Lymphocytes ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Lymphoid Tissue - cytology ; Male ; Mast-Cell Sarcoma - immunology ; Medical immunity ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Neoplasm Transplantation ; Regulation ; Spleen ; Spleen cells ; Stem cells ; T lymphocytes ; T-Lymphocytes - immunology ; T-Lymphocytes, Cytotoxic - immunology ; Transcription (Genetics) ; Transcription Factors - genetics ; Transcription Factors - physiology
É parte de: Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5299), p.540-543
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.
Editor: Washington, DC: American Society for the Advancement of Science
Idioma: Inglês

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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Mittrücker, Hans-Willi ; Matsuyama, Toshifumi ; Grossman, Alex ; Kündig, Thomas M. ; Potter, Julia ; Shahinian, Arda ; Wakeham, Andrew ; Patterson, Bruce ; Ohashi, Pamela S. ; Mak, Tak W.

Washington, DC: American Society for the Advancement of Science

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