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Inflammasome Activation Can Mediate Tissue-Specific Pathogenesis or Protection in Staphylococcus aureus Infection

Backert, Steffen

Current topics in microbiology and immunology, 2016, Vol.397, p.257-282 [Periódico revisado por pares]

Switzerland: Springer International Publishing AG

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Título:
Inflammasome Activation Can Mediate Tissue-Specific Pathogenesis or Protection in Staphylococcus aureus Infection
Autor: Backert, Steffen
Assuntos: Animals ; Hemolysin ; Host-Pathogen Interactions ; Host–pathogen interaction ; Humans ; Infectious & contagious diseases ; Inflammasomes - genetics ; Inflammasomes - immunology ; Innate immune ; Leukotoxin ; Macrophage ; Medical microbiology & virology ; Medical parasitology ; Monocyte ; Neutrophil ; Pathogenesis ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus - genetics ; Staphylococcus aureus - immunology ; Staphylococcus aureus - pathogenicity ; Staphylococcus aureus - physiology ; Virulence
É parte de: Current topics in microbiology and immunology, 2016, Vol.397, p.257-282
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Staphylococcus aureus is a Gram-positive coccus that interacts with human hosts on a spectrum from quiet commensal to deadly pathogen. S. aureus is capable of infecting nearly every tissue in the body resulting in cellulitis, pneumonia, osteomyelitis, endocarditis, brain abscesses, bacteremia, and more. S. aureus has a wide range of factors that promote infection, and each site of infection triggers a different response in the human host. In particular, the different patterns of inflammasome activation mediate tissue-specific pathogenesis or protection in S. aureus infection. Although still a nascent field, understanding the unique host–pathogen interactions in each infection and the role of inflammasomes in mediating pathogenesis may lead to novel strategies for treating S. aureus infections. Reviews addressing S. aureus virulence and pathogenesis (Thammavongsa et al. 2015), as well as epidemiology and pathophysiology (Tong et al. 2015), have recently been published. This review will focus on S. aureus factors that activate inflammasomes and their impact on innate immune signaling and bacterial survival.
Títulos relacionados: Current Topics in Microbiology and Immunology
Editor: Switzerland: Springer International Publishing AG
Idioma: Inglês

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Inflammasome Activation Can Mediate Tissue-Specific Pathogenesis or Protection in Staphylococcus aureus Infection

Backert, Steffen

Switzerland: Springer International Publishing AG

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