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Nrf2 signaling pathway: Pivotal roles in inflammation

Ahmed, Syed Minhaj Uddin ; Luo, Lin ; Namani, Akhileshwar ; Wang, Xiu Jun ; Tang, Xiuwen

Biochimica et biophysica acta. Molecular basis of disease, 2017-02, Vol.1863 (2), p.585-597 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Nrf2 signaling pathway: Pivotal roles in inflammation
  • Autor: Ahmed, Syed Minhaj Uddin ; Luo, Lin ; Namani, Akhileshwar ; Wang, Xiu Jun ; Tang, Xiuwen
  • Assuntos: Animals ; ARE ; Humans ; Inflammation ; Inflammation - immunology ; Keap1 ; NF-E2-Related Factor 2 - immunology ; NF-kappa B - immunology ; NLR Family, Pyrin Domain-Containing 3 Protein - immunology ; Nrf2 ; Oxidative stress ; Phytochemical ; Signal Transduction
  • É parte de: Biochimica et biophysica acta. Molecular basis of disease, 2017-02, Vol.1863 (2), p.585-597
  • Descrição: Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process by orchestrating the recruitment of inflammatory cells and regulating gene expression through the antioxidant response element (ARE). The Keap1 (Kelch-like ECH-associated protein)/Nrf2 (NF-E2 p45-related factor 2)/ARE signaling pathway mainly regulates anti-inflammatory gene expression and inhibits the progression of inflammation. Therefore, the identification of new Nrf2-dependent anti-inflammatory phytochemicals has become a key point in drug discovery. In this review, we discuss the members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway. In addition we also discuss about the regulation of NLRP3 inflammasome by Nrf2. Besides this, we summarize the current scenario of the development of anti-inflammatory phytochemicals and others that mediate the Nrf2/ARE signaling pathway. •Nrf2 involves in inflammatory diseases.•Crosstalk between Nrf2 and NF-ĸB pathways.•Nrf2 regulates NLRP3 inflammasome activity.•Nrf2 pathway could be therapeutically exploited.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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