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1,2-diacylglycerol content in myocardium from spontaneously hypertensive rats during the development of hypertension

KONDO, J ; YAMADA, Y ; OKUMURA, K ; HASHIMOTO, H ; ITO, T ; SATAKE, T

Basic research in cardiology, 1990-09, Vol.85 (5), p.453-460 [Periódico revisado por pares]

Heidelberg: Springer

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  • Título:
    1,2-diacylglycerol content in myocardium from spontaneously hypertensive rats during the development of hypertension
  • Autor: KONDO, J ; YAMADA, Y ; OKUMURA, K ; HASHIMOTO, H ; ITO, T ; SATAKE, T
  • Assuntos: Aging - metabolism ; Animals ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiology. Vascular system ; Diglycerides - metabolism ; Hypertension - metabolism ; Hypertension - physiopathology ; Male ; Medical sciences ; Myocardium - metabolism ; Phospholipids - metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reference Values ; Systole
  • É parte de: Basic research in cardiology, 1990-09, Vol.85 (5), p.453-460
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: 1,2-Diacylglycerol (DAG) has been considered to play an important role as an activator of protein kinase C in the signal transduction of inositol phospholipid metabolism. To examine the relation of 1,2-DAG in heart tissues to cardiac hypertrophy associated with hypertension, we measured the amount of 1,2-DAG in spontaneously hypertensive rat (SHR) hearts at 4, 10 and 20 weeks of age, and in age-matched normotensive Wistar-Kyoto (WKY) rat hearts using thin-layer chromatography with flame ionization detection (TLC-FID). Significant cardiac hypertrophy was found in 4-week-old SHR, while SHR did not yet have significant hypertension. Major phospholipids such as phosphatidylcholine and phosphatidylethanolamine increased from 4 to 20 weeks in the myocardium, but there was no difference between the two strains. The cholesterol levels of 4- and 20-week-old SHR were significantly higher than WKY rats. The 1,2-DAG contents of SHR hearts were significantly higher than WKY rats at 4 weeks. An increase in the RNA content was also observed in 4-week-old SHR hearts. However, analysis of the fatty acid composition of 1,2-DAG revealed no difference between the two strains. However, there was no significant difference in the 1,2-DAG content or in its fatty acid composition between SHR and WKY rat hearts at 10 and 20 weeks of age. It is suggested that an increase in the 1,2-DAG content of SHR hearts during the early stages appears related to the initiation of cardiac hypertrophy in SHR hearts before developed hypertension.
  • Editor: Heidelberg: Springer
  • Idioma: Inglês
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