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A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

Doria, F ; Nadai, M ; Zuffo, M ; Perrone, R ; Freccero, M ; Richter, S N

Chemical communications (Cambridge, England), 2017-02, Vol.53 (14), p.2268-2271 [Periódico revisado por pares]

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Título:
A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
Autor: Doria, F ; Nadai, M ; Zuffo, M ; Perrone, R ; Freccero, M ; Richter, S N
Assuntos: Agglomeration ; Antibodies ; Antibodies - chemistry ; Antibodies - immunology ; Binding ; Cell Nucleus - genetics ; Cell Nucleus - metabolism ; Chromosomal Proteins, Non-Histone - immunology ; Deoxyribonucleic acid ; Diimide ; Displacement ; Dyes ; Fluorescence ; Fluorescent Dyes - chemistry ; Fluorescent Dyes - metabolism ; G-Quadruplexes ; HEK293 Cells ; Humans ; Imides - chemistry ; Imides - metabolism ; Microscopy, Confocal ; Naphthalenes - chemistry ; Naphthalenes - metabolism ; Spectrometry, Fluorescence
É parte de: Chemical communications (Cambridge, England), 2017-02, Vol.53 (14), p.2268-2271
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.
Editor: England
Idioma: Inglês

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