Idioma:

Broad and potent neutralization of HIV―1 by a gp41―specific human antibody

JINGHE HUANG ; OFEK, Gilad ; MUNIR ALAM, S ; TAO WANG ; YONGPING YANG ; BAOSHAN ZHANG ; MIGUELES, Stephen A ; WYATT, Richard ; HAYNES, Barton F ; KWONG, Peter D ; MASCOLA, John R ; CONNORS, Mark ; LAUB, Leo ; LOUDER, Mark K ; DORIA-ROSE, Nicole A ; LONGO, Nancy S ; IMAMICHI, Hiromi ; BAILER, Robert T ; CHAKRABARTI, Bimal ; SHARMA, Shailendra K

Nature (London), 2012-11, Vol.491 (7424), p.406-412 [Periódico revisado por pares]

London: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Broad and potent neutralization of HIV―1 by a gp41―specific human antibody
Autor: JINGHE HUANG ; OFEK, Gilad ; MUNIR ALAM, S ; TAO WANG ; YONGPING YANG ; BAOSHAN ZHANG ; MIGUELES, Stephen A ; WYATT, Richard ; HAYNES, Barton F ; KWONG, Peter D ; MASCOLA, John R ; CONNORS, Mark ; LAUB, Leo ; LOUDER, Mark K ; DORIA-ROSE, Nicole A ; LONGO, Nancy S ; IMAMICHI, Hiromi ; BAILER, Robert T ; CHAKRABARTI, Bimal ; SHARMA, Shailendra K
Assuntos: Amino Acid Substitution ; Analytical, structural and metabolic biochemistry ; Antibodies ; Antibodies, Neutralizing - chemistry ; Antibodies, Neutralizing - metabolism ; Antibody Specificity ; Biological and medical sciences ; Cell culture ; Cells, Cultured ; Crystal structure ; Flow cytometry ; Fundamental and applied biological sciences. Psychology ; HEK293 Cells ; HIV Antibodies - chemistry ; HIV Antibodies - isolation & purification ; HIV Antibodies - metabolism ; HIV Envelope Protein gp41 - chemistry ; HIV Envelope Protein gp41 - immunology ; HIV infection ; HIV-1 - physiology ; Human immunodeficiency virus 1 ; Humans ; Lipids ; Models, Molecular ; Molecular and cellular biology ; Molecular Sequence Data ; Peptides ; Prevention ; Product development ; Properties ; Protein Binding ; Protein Structure, Tertiary ; Vaccines ; Viral antibodies
É parte de: Nature (London), 2012-11, Vol.491 (7424), p.406-412
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Equal contribution
Descrição: Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, which neutralizes ∼98% of tested viruses. An analysis of sera from 78 healthy HIV-1-infected donors demonstrated that 27% contained MPER-specific antibodies and 8% contained 10E8-like specificities. In contrast to other neutralizing MPER antibodies, 10E8 did not bind phospholipids, was not autoreactive, and bound cell-surface envelope. The structure of 10E8 in complex with the complete MPER revealed a site of vulnerability comprising a narrow stretch of highly conserved gp41-hydrophobic residues and a critical arginine or lysine just before the transmembrane region. Analysis of resistant HIV-1 variants confirmed the importance of these residues for neutralization. The highly conserved MPER is a target of potent, non-self-reactive neutralizing antibodies, suggesting that HIV-1 vaccines should aim to induce antibodies to this region of HIV-1 envelope glycoprotein.
Editor: London: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 5 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Broad and potent neutralization of HIV―1 by a gp41―specific human antibody

London: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.