Idioma:

Multiscale Analyses of the Bone-implant Interface

Cha, J.Y. ; Pereira, M.D. ; Smith, A.A. ; Houschyar, K.S. ; Yin, X. ; Mouraret, S. ; Brunski, J.B. ; Helms, J.A.

Journal of dental research, 2015-03, Vol.94 (3), p.482-490 [Periódico revisado por pares]

Los Angeles, CA: SAGE Publications

Texto completo disponível

Citações Citado por

Enviar para

Título:
Multiscale Analyses of the Bone-implant Interface
Autor: Cha, J.Y. ; Pereira, M.D. ; Smith, A.A. ; Houschyar, K.S. ; Yin, X. ; Mouraret, S. ; Brunski, J.B. ; Helms, J.A.
Assuntos: Animals ; Apoptosis ; Apoptosis - physiology ; Biomechanical Phenomena ; Bone growth ; Bone implants ; Bone matrix ; Bone Remodeling - physiology ; Bone resorption ; Bone Resorption - physiopathology ; Calcification, Physiologic - physiology ; Cell Death - physiology ; Cell Survival - physiology ; Collagen ; Collagen - metabolism ; Death & dying ; Dental Implantation, Endosseous - methods ; Dental Implants ; Dental Materials - chemistry ; Dental Prosthesis Retention ; Dentistry ; Elastic Modulus ; Femur - anatomy & histology ; Femur - injuries ; Femur - surgery ; Finite Element Analysis ; Fractures ; Laboratory animals ; Loading ; Male ; Mice ; Mineralization ; Orthodontics ; Osseointegration - physiology ; Osteocytes ; Osteocytes - pathology ; Osteogenesis ; Osteogenesis - physiology ; Osteotomy ; Osteotomy - methods ; Phosphatase ; Pliability ; Research Reports ; Stress, Mechanical ; Surface Properties ; Teeth ; Titanium ; Titanium - chemistry ; Torque ; Transplants & implants
É parte de: Journal of dental research, 2015-03, Vol.94 (3), p.482-490
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Implants placed with high insertion torque (IT) typically exhibit primary stability, which enables early loading. Whether high IT has a negative impact on peri-implant bone health, however, remains to be determined. The purpose of this study was to ascertain how peri-implant bone responds to strains and stresses created when implants are placed with low and high IT. Titanium micro-implants were inserted into murine femurs with low and high IT using torque values that were scaled to approximate those used to place clinically sized implants. Torque created in peri-implant tissues a distribution and magnitude of strains, which were calculated through finite element modeling. Stiffness tests quantified primary and secondary implant stability. At multiple time points, molecular, cellular, and histomorphometric analyses were performed to quantitatively determine the effect of high and low strains on apoptosis, mineralization, resorption, and collagen matrix deposition in peri-implant bone. Preparation of an osteotomy results in a narrow zone of dead and dying osteocytes in peri-implant bone that is not significantly enlarged in response to implants placed with low IT. Placing implants with high IT more than doubles this zone of dead and dying osteocytes. As a result, peri-implant bone develops micro-fractures, bone resorption is increased, and bone formation is decreased. Using high IT to place an implant creates high interfacial stress and strain that are associated with damage to peri-implant bone and therefore should be avoided to best preserve the viability of this tissue.
Editor: Los Angeles, CA: SAGE Publications
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Multiscale Analyses of the Bone-implant Interface

Cha, J.Y. ; Pereira, M.D. ; Smith, A.A. ; Houschyar, K.S. ; Yin, X. ; Mouraret, S. ; Brunski, J.B. ; Helms, J.A.

Los Angeles, CA: SAGE Publications

Buscando em bases de dados remotas. Favor aguardar.