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Intravenous immunoglobulin therapy among pediatric patients: labeled and off-labeled indications

Toh, Chin Chiang; Islahudin, Farida; Ali, Adli; Shah, Noraida Mohamed

Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 1 (2018); e00008

Universidade de São Paulo. Faculdade de Ciências Farmacêuticas 2018-06-07

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  • Título:
    Intravenous immunoglobulin therapy among pediatric patients: labeled and off-labeled indications
  • Autor: Toh, Chin Chiang; Islahudin, Farida; Ali, Adli; Shah, Noraida Mohamed
  • Assuntos: Intravenous Immunoglobulin; Off-Label Indications; Pediatric Patients; Malaysia Hospital
  • É parte de: Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 1 (2018); e00008
  • Descrição: This study was designed to evaluate utilization patterns and clinical outcome of intravenous immunoglobulin (IVIG) therapy among pediatric patients in a tertiary hospital. Demographic data, IVIG prescribed, and clinical outcome were retrospectively reviewed from the pharmacy dispensing data and patient medical records between 2007 and 2014. One hundred and fifteen instances of IVIG administration to 108 pediatric patients were recorded. A total of 61 cases (53%) and 54 cases (47%) of the IVIG administered were for labeled and off-labeled indications, respectively. Age, weight, specialty, total IVIG usage, length of hospital stays, and mortality rate were found to be significantly associated with the indication being labeled or off-labeled (p;0.05). Guidelines should be developed and implemented for rational and evidence-based use of IVIG to avoid unnecessary wastage.
  • Títulos relacionados: https://www.revistas.usp.br/bjps/article/view/146817/140346
  • Editor: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
  • Data de criação/publicação: 2018-06-07
  • Formato: Adobe PDF
  • Idioma: Inglês
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