Idioma:

Management of Hypersensitivity Reactions to Carboplatin and Paclitaxel in an Outpatient Oncology Infusion Center: A 5-Year Review

Banerji, Aleena, MD ; Lax, Timothy, MD ; Guyer, Autumn, MD ; Hurwitz, Shelley, PhD ; Camargo, Carlos A., MD, DrPH ; Long, Aidan A., MD

The journal of allergy and clinical immunology in practice (Cambridge, MA), 2014-07, Vol.2 (4), p.428-433 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Management of Hypersensitivity Reactions to Carboplatin and Paclitaxel in an Outpatient Oncology Infusion Center: A 5-Year Review
Autor: Banerji, Aleena, MD ; Lax, Timothy, MD ; Guyer, Autumn, MD ; Hurwitz, Shelley, PhD ; Camargo, Carlos A., MD, DrPH ; Long, Aidan A., MD
Assuntos: Adult ; Age ; Aged ; Allergens - adverse effects ; Allergens - immunology ; Allergy ; Allergy and Immunology ; Ambulatory Care ; Back pain ; Back Pain - etiology ; Body mass index ; Cancer therapies ; Carboplatin - adverse effects ; Carboplatin - immunology ; Cardiovascular disease ; Coronary vessels ; Desensitization ; Desensitization, Immunologic - methods ; Diabetes ; Drug hypersensitivity ; Drug Hypersensitivity - immunology ; Drug Hypersensitivity - therapy ; Family medical history ; Female ; Humans ; Hypertension ; Infusion Pumps ; Internal Medicine ; Male ; Middle Aged ; Mortality ; Oncology ; Oncology Service, Hospital ; Ovarian cancer ; Paclitaxel - adverse effects ; Paclitaxel - immunology ; Patients ; Pruritus - etiology ; Retrospective Studies ; Statistical analysis ; Vomiting ; Womens health
É parte de: The journal of allergy and clinical immunology in practice (Cambridge, MA), 2014-07, Vol.2 (4), p.428-433
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Background A high incidence of hypersensitivity reactions (HSR) to carboplatin and Taxol is limiting the use of carboplatin and Taxol. Objective We conducted a 5-year study of all patients with HSR to carboplatin or Taxol to better understand the nature of infusion HSR and success or failure of management plans after the initial HSR. Methods We performed a retrospective chart review of all safety reports from the Massachusetts General Hospital outpatient chemotherapy infusion center between January 2006 and February 2011. All the patients with HSRs to carboplatin or Taxol were identified and included in the final analysis. We reviewed patient characteristics, clinical symptoms, timing, and treatment of the initial HSR, and determined if the patient was rechallenged despite an initial HSR. Results We identified 152 patients with HSR to carboplatin (n = 45) or Taxol (n = 107). Carboplatin HSR was less severe than Taxol HSR. When comparing the 2 groups, the patients with carboplatin HSRs more commonly described itchy palms and feet, generalized itch, and general urticaria and/or erythema, whereas patients with Taxol HSR more commonly described facial flushing, back pain, and chest or throat tightness (all P < .05). Among 40 patients with mild-to-moderate carboplatin HSRs, only 7 were rechallenged, and 100% tolerated rechallenge without desensitization. None of the patients with severe carboplatin HSRs (n = 5) were rechallenged. Most patients (75%) with Taxol HSRs were rechallenged, and 91% tolerated rechallenge without desensitization; the patients with a severe HSR to Taxol were less likely to be rechallenged. Conclusion The clinical symptoms and timing of carboplatin HSR are distinct from Taxol HSR. Most patients with carboplatin HSR were not rechallenged, whereas most patients with Taxol HSR were successfully rechallenged.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Management of Hypersensitivity Reactions to Carboplatin and Paclitaxel in an Outpatient Oncology Infusion Center: A 5-Year Review

Banerji, Aleena, MD ; Lax, Timothy, MD ; Guyer, Autumn, MD ; Hurwitz, Shelley, PhD ; Camargo, Carlos A., MD, DrPH ; Long, Aidan A., MD

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.