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Female advantage in verbal memory: Evidence of sex-specific cognitive reserve

Sundermann, Erin E ; Maki, Pauline M ; Rubin, Leah H ; Lipton, Richard B ; Landau, Susan ; Biegon, Anat

Neurology, 2016-11, Vol.87 (18), p.1916-1924 [Periódico revisado por pares]

United States: American Academy of Neurology

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  • Título:
    Female advantage in verbal memory: Evidence of sex-specific cognitive reserve
  • Autor: Sundermann, Erin E ; Maki, Pauline M ; Rubin, Leah H ; Lipton, Richard B ; Landau, Susan ; Biegon, Anat
  • Assuntos: Acoustic Stimulation ; Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - genetics ; Alzheimer Disease - physiopathology ; Apolipoproteins E - genetics ; Cognition Disorders - diagnostic imaging ; Cognition Disorders - genetics ; Cognition Disorders - physiopathology ; Cognitive Reserve - physiology ; Cross-Sectional Studies ; Female ; Fluorodeoxyglucose F18 - metabolism ; Humans ; Linear Models ; Male ; Mental Status Schedule ; Neuropsychological Tests ; Positron-Emission Tomography ; Sex Characteristics ; Verbal Learning - physiology
  • É parte de: Neurology, 2016-11, Vol.87 (18), p.1916-1924
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
    Alzheimer's Disease Neuroimaging Initiative coinvestigators are listed at Neurology.org.
    Data used in this study were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. As such, with the exception of Susan Landau, investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. The ADNI list can be found at Neurology.org.
  • Descrição: OBJECTIVE:We investigated sex differences in verbal memory across different levels of neural dysfunction, measured by temporal lobe glucose metabolic rates (TLGluMR). METHODS:Three hundred ninety controls and 672 participants with amnestic mild cognitive impairment (aMCI) and 254 with Alzheimer disease (AD) dementia from the Alzheimerʼs Disease Neuroimaging Initiative completed the Rey Auditory Verbal Learning Test (RAVLT) and [F]-fluorodeoxyglucose–PET. Cross-sectional analyses were conducted using linear regression to examine the sex by TLGluMR interaction on RAVLT performance in the overall sample and within diagnostic groups adjusting for age, education, and APOE ε4 genotype. RESULTS:Across groups, female sex and higher TLGluMR and their interaction were associated with better verbal memory (p values ≤ 0.005). The female advantage in verbal memory varied by TLGluMR such that the advantage was greatest among individuals with moderate to high TLGluMR and minimal or absent among individuals with lower TLGluMR. Diagnosis-stratified analyses revealed that this interaction was driven by the aMCI group (p values = 0.009). The interaction was not significant in control and AD dementia groups. CONCLUSIONS:Women show better verbal memory than men in aMCI despite similar levels of brain hypometabolism. The lifelong advantage that females show over males in verbal memory might represent a form of cognitive reserve that delays verbal memory decline until more advanced pathology, as indexed by TLGluMR. This issue is clinically important because verbal memory scores are used in diagnosing aMCI and AD dementia.
  • Editor: United States: American Academy of Neurology
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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