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Relationship between breast milk sCD 14, TGF ‐β1 and total I g A in the first month and development of eczema during infancy

Ismail, Intan H. ; Licciardi, Paul V. ; Oppedisano, Frances ; Boyle, Robert J. ; Tang, Mimi L. K.

Pediatric allergy and immunology, 2013-06, Vol.24 (4), p.352-360 [Periódico revisado por pares]

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  • Título:
    Relationship between breast milk sCD 14, TGF ‐β1 and total I g A in the first month and development of eczema during infancy
  • Autor: Ismail, Intan H. ; Licciardi, Paul V. ; Oppedisano, Frances ; Boyle, Robert J. ; Tang, Mimi L. K.
  • É parte de: Pediatric allergy and immunology, 2013-06, Vol.24 (4), p.352-360
  • Descrição: Abstract Introduction The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial. Objective We investigated the relationship between breast milk immunomodulatory factors and subsequent development of eczema and atopic sensitization in the first year of life. Methods Day 7 and 28 breast milk samples were collected from mothers carrying infants at high risk of allergic disease. Aqueous‐phase breast milk samples were assayed for TGF ‐β1, sCD 14 and total I g A . Infants were assessed for the presence of eczema and atopic sensitization at 12 months of age. The levels of breast milk TGF ‐β1, sCD 14 and total I g A were compared in infants who subsequently developed eczema and sensitization in the first year and those who did not. Results The levels of breast milk sCD 14, total I g A , and TGF ‐β1 at either day 7 or 28 were not associated with subsequent development of eczema or atopic sensitization during the first year of life. Conclusion Levels of breast milk immune parameters were not associated with eczema outcomes or sensitization in infants at 12 months. This suggests that apparent immunological effects on breast milk immunomodulatory factors may not necessarily lead to clinical benefits, and these immune markers may not be critical determinants of allergic disease in infancy.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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