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Maternal BMI Associations with Maternal and Cord Blood Vitamin D Levels in a North American Subset of Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Participants

Josefson, Jami L ; Reisetter, Anna ; Scholtens, Denise M ; Price, Heather E ; Metzger, Boyd E ; Langman, Craig B Nerurkar, Pratibha V.

PloS one, 2016-03, Vol.11 (3), p.e0150221-e0150221 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Maternal BMI Associations with Maternal and Cord Blood Vitamin D Levels in a North American Subset of Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Participants
Autor: Josefson, Jami L ; Reisetter, Anna ; Scholtens, Denise M ; Price, Heather E ; Metzger, Boyd E ; Langman, Craig B
Nerurkar, Pratibha V.
Assuntos: 25-Hydroxyvitamin D ; Adipose tissue ; Adult ; Biology and Life Sciences ; Birth weight ; Blood ; Blood levels ; Body mass ; Body Mass Index ; Childbirth & labor ; Cord blood ; Diseases ; Fasting ; Female ; Fetal Blood - metabolism ; Gestation ; Gestational age ; Glucose ; Glucose tolerance ; Glucose Tolerance Test ; Health aspects ; High-performance liquid chromatography ; Humans ; Hyperglycemia ; Hyperglycemia - blood ; Hyperglycemia - complications ; Infant, Newborn ; Insulin ; Latitude ; Linear Models ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Medicine and Health Sciences ; Neonates ; Newborn babies ; North America ; Obesity ; Physical sciences ; Physiological aspects ; Placenta ; Placental transfer ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Outcome ; Pregnant women ; Preventive medicine ; Regression analysis ; Regression models ; Risk factors ; Statistical analysis ; Variance analysis ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Womens health
É parte de: PloS one, 2016-03, Vol.11 (3), p.e0150221-e0150221
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Members of the HAPO Study Cooperative Research Group are listed in the Acknowledgments.
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: JLJ CBL. Performed the experiments: HEP. Analyzed the data: AR DMS. Wrote the paper: JLJ CBL. Obtained the funding to carry out this study: JLJ. Reviewed and edited the manuscript: DMS BEM. Head of the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study; contributed to the design of the study: BEM. Approved this ancillary study and reviewed the manuscript prior to journal submission: the HAPO Study Steering Committee.
Descrição: Obesity in pregnancy may be associated with reduced placental transfer of 25-hydroxyvitamin D (25-OHD). The objective of this study was to examine associations between maternal BMI and maternal and cord blood levels of 25-OHD in full term neonates born to a single racial cohort residing at similar latitude. Secondary objectives were to examine associations between maternal glucose tolerance with maternal levels of 25-OHD and the relationship between cord blood 25-OHD levels and neonatal size. This study was conducted among participants of the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study meeting the following criteria: residing at latitudes 41-43°, maternal white race, and gestational age 39-41 weeks. Healthy pregnant women underwent measures of height, weight, and a 75-g fasting oral glucose tolerance test (OGTT) at approximately 28 weeks gestation. Maternal and cord blood sera were analyzed for total 25-OHD by HPLC tandem mass spectrometry. Statistical analyses included ANOVA and linear regression models. Maternal and cord blood (N = 360) mean levels (sd) of 25-OHD were 37.2 (11.2) and 23.4 (9.2) ng/ml, respectively, and these levels were significantly different among the 3 field centers (ANOVA p< 0.001). Maternal serum 25-OHD was lower by 0.40 ng/ml for BMI higher by 1 kg/m2 (p<0.001) in an adjusted model. Maternal fasting plasma glucose, insulin sensitivity, and presence of GDM were not associated with maternal serum 25-OHD level when adjusted for maternal BMI. Cord blood 25-OHD was lower by 0.26 ng/ml for maternal BMI higher by 1 kg/m2 (p<0.004). With adjustment for maternal age, field center, birth season and maternal serum 25-OHD, the association of cord blood 25-OHD with maternal BMI was attenuated. Neither birth weight nor neonatal adiposity was significantly associated with cord blood 25-OHD levels. These results suggest that maternal levels of 25-OHD are associated with maternal BMI. The results also suggest that interpretation of neonatal 25-OHD levels may need to incorporate specific maternal factors in addition to season of birth and latitude.
Editor: United States: Public Library of Science
Idioma: Inglês

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Maternal BMI Associations with Maternal and Cord Blood Vitamin D Levels in a North American Subset of Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Participants

Josefson, Jami L ; Reisetter, Anna ; Scholtens, Denise M ; Price, Heather E ; Metzger, Boyd E ; Langman, Craig B Nerurkar, Pratibha V.

United States: Public Library of Science

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