Idioma:

Ablation of Hippocampal Neurogenesis Impairs Contextual Fear Conditioning and Synaptic Plasticity in the Dentate Gyrus

Saxe, Michael D. ; Battaglia, Fortunato ; Wang, Jing-Wen ; Malleret, Gael ; David, Denis J. ; Monckton, James E. ; Garcia, A. Denise R. ; Sofroniew, Michael V. ; Kandel, Eric R. ; Santarelli, Luca ; Hen, René ; Drew, Michael R.

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17501-17506 [Periódico revisado por pares]

United States: National Academy of Sciences

Texto completo disponível

Citações Citado por

Enviar para

Título:
Ablation of Hippocampal Neurogenesis Impairs Contextual Fear Conditioning and Synaptic Plasticity in the Dentate Gyrus
Autor: Saxe, Michael D. ; Battaglia, Fortunato ; Wang, Jing-Wen ; Malleret, Gael ; David, Denis J. ; Monckton, James E. ; Garcia, A. Denise R. ; Sofroniew, Michael V. ; Kandel, Eric R. ; Santarelli, Luca ; Hen, René ; Drew, Michael R.
Assuntos: Anatomy & physiology ; Animals ; Behavioral neuroscience ; Biological Sciences ; Cells ; Conditioning (Psychology) ; Electrophysiology ; Fear - physiology ; Freezing ; Glial Fibrillary Acidic Protein - genetics ; Glial Fibrillary Acidic Protein - metabolism ; Hippocampus ; Hippocampus - physiology ; Irradiation ; Light ; Long term potentiation ; Male ; Mammals ; Mazes ; Memory ; Mice ; Mice, Transgenic ; Neurogenesis ; Neuronal Plasticity - physiology ; Neurons ; Neurons - physiology ; Studies ; Thymidine Kinase - genetics ; Thymidine Kinase - metabolism
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17501-17506
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author contributions: M.D.S., G.M., D.J.D., L.S., R.H., and M.R.D. designed research; M.D.S., F.B., J.-W.W., G.M., D.J.D., J.E.M., A.D.R.G., and M.R.D. performed research; M.D.S., A.D.R.G., M.V.S., E.R.K., L.S., and R.H. contributed new reagents/analytic tools; M.D.S., F.B., J.-W.W., G.M., D.J.D., A.D.R.G., R.H., and M.R.D. analyzed data; and M.D.S., L.S., R.H., and M.R.D. wrote the paper.
Communicated by Gerald D. Fischbach, Columbia University College of Physicians and Surgeons, New York, NY, September 20, 2006
Descrição: Although hippocampal neurogenesis has been described in many adult mammals, the functional impact of this process on physiology and behavior remains unclear. In the present study, we used two independent methods to ablate hippocampal neurogenesis and found that each procedure caused a limited behavioral deficit and a loss of synaptic plasticity within the dentate gyrus. Specifically, focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells impaired contextual fear conditioning but not cued conditioning. Hippocampal-dependent spatial learning tasks such as the Morris water maze and Y maze were unaffected. These findings show that adult-born neurons make a distinct contribution to some but not all hippocampal functions. In a parallel set of experiments, we show that long-term potentiation elicited in the dentate gyrus in the absence of GABA blockers requires the presence of new neurons, as it is eliminated by each of our ablation procedures. These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior.
Editor: United States: National Academy of Sciences
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Ablation of Hippocampal Neurogenesis Impairs Contextual Fear Conditioning and Synaptic Plasticity in the Dentate Gyrus

Saxe, Michael D. ; Battaglia, Fortunato ; Wang, Jing-Wen ; Malleret, Gael ; David, Denis J. ; Monckton, James E. ; Garcia, A. Denise R. ; Sofroniew, Michael V. ; Kandel, Eric R. ; Santarelli, Luca ; Hen, René ; Drew, Michael R.

United States: National Academy of Sciences

Buscando em bases de dados remotas. Favor aguardar.