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Role of Scl39a13/ZIP13 in cardiovascular homeostasis

Hara, Takafumi ; Yamada, Ikuko ; Ohashi, Takuto ; Tamura, Masaru ; Hijikata, Atsushi ; Watanabe, Takashi ; Gao, Minghao ; Ito, Kana ; Kawamata, Saeko ; Azuma, Shiori ; Yoshigai, Emi ; Sumiyoshi, Yukiko ; Yasuhiro, Natsumi ; Ohara, Osamu ; Santos, Heloísa G. dos ; Fukada, Toshiyuki Zhou, Lufang

PloS one, 2022-10, Vol.17 (10), p.e0276452-e0276452 [Periódico revisado por pares]

San Francisco: Public Library of Science

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Título:
Role of Scl39a13/ZIP13 in cardiovascular homeostasis
Autor: Hara, Takafumi ; Yamada, Ikuko ; Ohashi, Takuto ; Tamura, Masaru ; Hijikata, Atsushi ; Watanabe, Takashi ; Gao, Minghao ; Ito, Kana ; Kawamata, Saeko ; Azuma, Shiori ; Yoshigai, Emi ; Sumiyoshi, Yukiko ; Yasuhiro, Natsumi ; Ohara, Osamu ; Santos, Heloísa G. dos ; Fukada, Toshiyuki
Zhou, Lufang
Assuntos: Animal tissues ; Biology and Life Sciences ; Cardiac arrhythmia ; Cardiomyocytes ; Cardiovascular diseases ; Cardiovascular research ; Cardiovascular system ; Carrier proteins ; Cell adhesion ; Collagen (type I) ; Coronary artery disease ; Doxycycline ; Echocardiography ; Fibrosis ; Gene expression ; Genes ; Genetic aspects ; Golgi apparatus ; Growth rate ; Health aspects ; Heart ; Heart diseases ; Homeostasis ; Inflammation ; Kinases ; Medicine and Health Sciences ; Morphology ; Mortality ; mRNA ; Mutation ; Neonates ; Osteopenia ; Physiological aspects ; Physiology ; Research and Analysis Methods ; Stress response ; Telemetry ; Therapeutic targets ; Variance analysis ; Zinc ; Zinc in the body ; Zinc transporter
É parte de: PloS one, 2022-10, Vol.17 (10), p.e0276452-e0276452
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
Current address: School of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Descrição: Zinc plays a critical role in many physiological processes, and disruption of zinc homeostasis induces various disorders, such as growth retardation, osteopenia, immune deficiency, and inflammation. However, how the imbalance in zinc homeostasis leads to heart disease is not yet fully understood. Cardiovascular diseases are a major cause of death worldwide, and the development of novel therapeutic targets to treat it is urgently needed. We report that a zinc transporter, ZIP13, regulates cardiovascular homeostasis. We found that the expression level of Zip13 mRNA was diminished in both primary neonatal cardiomyocytes and mouse heart tissues treated with the cardiotoxic agent doxycycline. Primary neonatal cardiomyocytes from Zip13 gene-knockout (KO) mice exhibited abnormal irregular arrhythmic beating. RNA-seq analysis identified 606 differentially expressed genes in Zip13-KO mouse-derived primary neonatal cardiomyocytes and Gene ontology (GO) analysis revealed that both inflammation- and cell adhesion-related genes were significantly enriched. In addition, telemetry echocardiography analysis suggested that arrhythmias were likely to occur in Zip13-KO mice, in which elevated levels of the cardiac fibrosis marker Col1a1, vascular inflammation-related gene eNOS, and Golgi-related molecule GM130 were observed. These results indicate the physiological importance of ZIP13-it maintains cardiovascular homeostasis by resolving inflammation and stress response. Our findings suggest that optimizing ZIP13 expression and/or function may improve cardiovascular disease management.
Editor: San Francisco: Public Library of Science
Idioma: Inglês

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Role of Scl39a13/ZIP13 in cardiovascular homeostasis

Hara, Takafumi ; Yamada, Ikuko ; Ohashi, Takuto ; Tamura, Masaru ; Hijikata, Atsushi ; Watanabe, Takashi ; Gao, Minghao ; Ito, Kana ; Kawamata, Saeko ; Azuma, Shiori ; Yoshigai, Emi ; Sumiyoshi, Yukiko ; Yasuhiro, Natsumi ; Ohara, Osamu ; Santos, Heloísa G. dos ; Fukada, Toshiyuki Zhou, Lufang

San Francisco: Public Library of Science

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