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The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease

OLIVEIRA, J. R. M ; GALLINDO, R. M ; MAIA, L. G. S ; BRITO-MARQUES, P. R ; OTTO, P. A ; PASSOS-BUENOS, M. R ; MORAIS, M. A ; ZATZ, M

Molecular psychiatry, 1998-09, Vol.3 (5), p.438-441 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease
Autor: OLIVEIRA, J. R. M ; GALLINDO, R. M ; MAIA, L. G. S ; BRITO-MARQUES, P. R ; OTTO, P. A ; PASSOS-BUENOS, M. R ; MORAIS, M. A ; ZATZ, M
Assuntos: Adult ; Age ; Age of Onset ; Aged ; Alleles ; Alzheimer Disease - epidemiology ; Alzheimer Disease - genetics ; Alzheimer's disease ; Biological and medical sciences ; Carrier Proteins - genetics ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Gene deletion ; Gene Frequency ; Gene polymorphism ; Genetic Variation ; Genotype ; Humans ; Insertion ; Medical sciences ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Middle Aged ; Nerve Tissue Proteins - genetics ; Neurodegenerative diseases ; Neurology ; Polymorphism ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Reference Values ; Risk Factors ; Serotonin ; Serotonin Plasma Membrane Transport Proteins ; Serotonin transporter ; Statistical analysis
É parte de: Molecular psychiatry, 1998-09, Vol.3 (5), p.438-441
Notas: ObjectType-Article-2
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Descrição: We analyzed a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-HTTPLR) in 81 patients with late onset Alzheimer's (AD) disease (mean age 70.02 +/- 8.13 years). Control groups included 81 normal subjects with comparable age (mean age 75.6 +/- 10.2) and 82 younger normal subjects (mean age 37.4 +/- 9.1). Statistical analysis showed a significant difference in the genotype and gene frequencies between the AD group and normal controls (chi 2 = 9.021; 2 d.f. and chi 2 = 5.59, 1 d.f., respectively, P < 0.05) due to the higher frequency of the L allele and the lower frequency of the s allele in controls than among AD patients. However, no differences were found in the genotype frequencies in older as compared to younger normal control groups (chi 2 = 0.337, 2 d.f. and P > 0.05). The present study confirms, in a different population, that the short variant of the 5-HTTPLR polymorphism may be a risk factor for late onset AD.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease

OLIVEIRA, J. R. M ; GALLINDO, R. M ; MAIA, L. G. S ; BRITO-MARQUES, P. R ; OTTO, P. A ; PASSOS-BUENOS, M. R ; MORAIS, M. A ; ZATZ, M

Basingstoke: Nature Publishing Group

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