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Cell circuits and niches controlling B cell development

Zehentmeier, Sandra ; Pereira, João P.

Immunological reviews, 2019-05, Vol.289 (1), p.142-157 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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Título:
Cell circuits and niches controlling B cell development
Autor: Zehentmeier, Sandra ; Pereira, João P.
Assuntos: Acute lymphoblastic leukemia ; Animals ; B-Lymphocytes - physiology ; cell circuits ; Cell Differentiation ; Cells (biology) ; Cellular Microenvironment ; Chemokine CXCL12 - metabolism ; Chemokines ; Circuits ; CXCL12 ; Cytokines ; Endothelial cells ; Endothelial Cells - physiology ; hematopoiesis ; Hematopoietic stem cells ; Hematopoietic Stem Cells - physiology ; Humans ; interleukin 7 ; Interleukin-7 - metabolism ; Interleukins ; Leukemia ; Lymphocytes B ; Lymphoid cells ; lymphoid commitment ; Lymphopoiesis ; Mesenchymal Stem Cells - physiology ; Mesenchyme ; Microenvironments ; Progenitor cells ; Stem cell factor ; Stem Cell Niche ; Stem cells
É parte de: Immunological reviews, 2019-05, Vol.289 (1), p.142-157
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Summary Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small subset of endothelial cells. Niche cells create specialized microenvironments through the concomitant production of short‐range acting cell‐fate determining cytokines such as interleukin (IL)‐7 and stem cell factor and the potent chemoattractant C‐X‐C motif chemokine ligand 12. This type of cellular organization allows for the cross‐talk between hematopoietic stem and progenitor cells with niche cells, such that niche cell activity can be regulated by the quality and quantity of hematopoietic progenitors being produced. For example, preleukemic B cell progenitors and preB acute lymphoblastic leukemias interact directly with MPCs, and downregulate IL‐7 expression and the production of non‐leukemic lymphoid cells. In this review, we discuss a novel model of B cell development that is centered on cellular circuits formed between B cell progenitors and lymphopoietic niches.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

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Cell circuits and niches controlling B cell development

Zehentmeier, Sandra ; Pereira, João P.

England: Wiley Subscription Services, Inc

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