Idioma:

Non-coding variability at the APOE locus contributes to the Alzheimer's risk

Zhou, Xiaopu ; Chen, Yu ; Mok, Kin Y ; Kwok, Timothy C Y ; Mok, Vincent C T ; Guo, Qihao ; Ip, Fanny C ; Chen, Yuewen ; Mullapudi, Nandita ; Giusti-Rodríguez, Paola ; Sullivan, Patrick F ; Hardy, John ; Fu, Amy K Y ; Li, Yun ; Ip, Nancy Y

Nature communications, 2019-07, Vol.10 (1), p.3310-16, Article 3310 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Non-coding variability at the APOE locus contributes to the Alzheimer's risk
Autor: Zhou, Xiaopu ; Chen, Yu ; Mok, Kin Y ; Kwok, Timothy C Y ; Mok, Vincent C T ; Guo, Qihao ; Ip, Fanny C ; Chen, Yuewen ; Mullapudi, Nandita ; Giusti-Rodríguez, Paola ; Sullivan, Patrick F ; Hardy, John ; Fu, Amy K Y ; Li, Yun ; Ip, Nancy Y
Assuntos: Aged ; Aged, 80 and over ; Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Alzheimer Disease - psychology ; Alzheimer's disease ; Apolipoprotein E ; Apolipoproteins C - genetics ; Apolipoproteins C - metabolism ; Apolipoproteins E - genetics ; Apolipoproteins E - metabolism ; Brain ; Brain - metabolism ; Case-Control Studies ; Chromatin ; Chromosomes ; Cognition ; Cognitive ability ; Conformation ; Female ; Gene Expression ; Genetic Predisposition to Disease ; Genetic Variation ; Genomes ; Geriatrics ; Haplotypes ; Health risks ; Humans ; Loci ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Nectins - genetics ; Nectins - metabolism ; Non-coding RNA ; Pathogenesis ; Polymorphism, Single Nucleotide ; Risk analysis ; Risk factors
É parte de: Nature communications, 2019-07, Vol.10 (1), p.3310-16, Article 3310
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Alzheimer's disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the risk effect conferred by the locus. Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change. These risk haplotypes are associated with changes of AD-related endophenotypes including cognitive performance, and altered expression of APOE and its nearby genes in the human brain and blood. High-throughput genome-wide chromosome conformation capture analysis further supports the roles of these risk haplotypes in modulating chromatin states and gene expression in the brain. Our findings provide compelling evidence for additional risk factors in the APOE locus that contribute to AD pathogenesis.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Non-coding variability at the APOE locus contributes to the Alzheimer's risk

Zhou, Xiaopu ; Chen, Yu ; Mok, Kin Y ; Kwok, Timothy C Y ; Mok, Vincent C T ; Guo, Qihao ; Ip, Fanny C ; Chen, Yuewen ; Mullapudi, Nandita ; Giusti-Rodríguez, Paola ; Sullivan, Patrick F ; Hardy, John ; Fu, Amy K Y ; Li, Yun ; Ip, Nancy Y

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.