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Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle

Yding Andersen, C

Molecular human reproduction, 2017-01, Vol.23 (1), p.16-24 [Periódico revisado por pares]

England

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Título:
Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle
Autor: Yding Andersen, C
Assuntos: Androgens - biosynthesis ; Androgens - secretion ; Aromatase - genetics ; Aromatase - metabolism ; Estradiol - biosynthesis ; Estradiol - secretion ; Female ; Follicle Stimulating Hormone - genetics ; Follicle Stimulating Hormone - metabolism ; Follicular Phase - genetics ; Follicular Phase - metabolism ; Gene Expression Regulation, Developmental ; Granulosa Cells - cytology ; Granulosa Cells - metabolism ; Humans ; Inhibins - genetics ; Inhibins - metabolism ; Inhibins - secretion ; Luteinizing Hormone - genetics ; Luteinizing Hormone - metabolism ; Protein Isoforms - genetics ; Protein Isoforms - metabolism ; Receptors, FSH - genetics ; Receptors, FSH - metabolism ; Receptors, LH - genetics ; Receptors, LH - metabolism ; Signal Transduction ; Theca Cells - cytology ; Theca Cells - metabolism
É parte de: Molecular human reproduction, 2017-01, Vol.23 (1), p.16-24
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The aim of the present paper is to expand the concept on how follicular selection takes place in the follicular phase of the natural menstrual cycle. It is suggested that inhibin-B exerts a more intimate role in this process than previously understood. Inhibin-B shows a peak in the circulation around cycle day 7, simultaneous with selection of the dominant follicle, whereas levels of estradiol and inhibin-A only start to increase a few days later suggesting that inhibin-B is mainly responsible for downregulating pituitary FSH release. New data now demonstrate that the circulatory peak of inhibin-B is reflected by peak production of inhibin-B, in contrast to inhibin-A, in the selected follicle with a diameter of 10-12 mm, where concentrations are one thousand times higher than in the circulation. This high inhibin-B concentration also exerts paracrine effects, stimulating theca cell androgen production in concert with LH. New data now suggest that in the corresponding granulosa cells androgens upregulate FSH receptor (FSHR) and LH receptor (LHR) mRNA expression, which in turn stimulate CYP19a mRNA expression providing the follicles which most effectively undertake these processes with the best chance of becoming selected. Inhibin-B production is stimulated by FSH and it appears that the acidic isoforms of FSH induce inhibin-B secretion most efficiently thereby, for the first time, placing the changing FSH isoform profile during the follicular phase in a physiological context. Collectively, it appears that inhibin-B is an integral part of follicular selection in the normal menstrual cycle, exerting both endocrine and paracrine effects and facilitating continued growth of the selected follicle.
Editor: England
Idioma: Inglês

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Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle

Yding Andersen, C

England

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