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Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil

Alcione Oliveira Santos Mónica V Alvarado-Mora; Lívia Botelho; Deusilene S Vieira; João R. Rebelho Pinho; Flair J Carrilho; Eduardo R Honda; Juan M Salcedo

Virology Journal London v. 7, n. 315, (on-line), 2010

London 2010

Acesso online. A biblioteca também possui exemplares impressos.

  • Título:
    Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil
  • Autor: Alcione Oliveira Santos
  • Mónica V Alvarado-Mora; Lívia Botelho; Deusilene S Vieira; João R. Rebelho Pinho; Flair J Carrilho; Eduardo R Honda; Juan M Salcedo
  • Assuntos: HEPATITE B (VIROLOGIA); GENÓTIPOS; REAÇÃO EM CADEIA POR POLIMERASE; RONDÔNIA
  • É parte de: Virology Journal London v. 7, n. 315, (on-line), 2010
  • Notas: Disponivél em: . Acesso em: 23 mar. 2011
  • Descrição: Background: Hepatitis B virus (HBV) can be classified into nine genotypes (A-I) defined by sequence divergence of more than 8% based on the complete genome. This study aims to identify the genotypic distribution of HBV in 40 HBsAg-positive patients from Rondônia, Brazil. A fragment of 1306 bp partially comprising surface and polymerase overlapping genes was amplified by PCR. Amplified DNA was purified and sequenced. Amplified DNA was purified and sequenced on an ABI PRISM® 377 Automatic Sequencer (Applied Biosystems, Foster City, CA, USA). The obtained sequences were aligned with reference sequences obtained from the GenBank using Clustal X software and then edited with Se-Al software. Phylogenetic analyses were conducted by the Markov Chain Monte Carlo (MCMC) approach using BEAST v.1.5.3. Results: The subgenotypes distribution was A1 (37.1%), D3 (22.8%), F2a (20.0%), D4 (17.1%) and D2 (2.8%). Conclusions: These results for the first HBV genotypic characterization in Rondônia state are consistent with other studies in Brazil, showing the presence of several HBV genotypes that reflects the mixed origin of the population, involving descendants from Native Americans, Europeans, and Africans
  • Editor: London
  • Data de criação/publicação: 2010
  • Formato: p. (on-line).
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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