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Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study

Oudin, Anna ; Forsberg, Bertil ; Adolfsson, Annelie Nordin ; Lind, Nina ; Modig, Lars ; Nordin, Maria ; Nordin, Steven ; Adolfsson, Rolf ; Nilsson, Lars-Göran

Environmental health perspectives, 2016-03, Vol.124 (3), p.306-312 [Periódico revisado por pares]

United States: National Institute of Environmental Health Sciences

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Título:
Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study
Autor: Oudin, Anna ; Forsberg, Bertil ; Adolfsson, Annelie Nordin ; Lind, Nina ; Modig, Lars ; Nordin, Maria ; Nordin, Steven ; Adolfsson, Rolf ; Nilsson, Lars-Göran
Assuntos: Adult ; Age ; Aged ; Aged, 80 and over ; Aging ; Air Pollutants - analysis ; Air Pollutants - toxicity ; Air Pollution ; Air Pollution - adverse effects ; Alzheimer Disease ; Alzheimer Disease - epidemiology ; Alzheimer Disease - etiology ; Alzheimer's disease ; Betula ; Cities - epidemiology ; Cognition & reasoning ; Cognitive ability ; Cohort analysis ; Cross-sectional studies ; Dementia ; Dementia, Vascular - epidemiology ; Dementia, Vascular - etiology ; Disease prevention ; Distribution ; Environmental Exposure - adverse effects ; Female ; Flow velocity ; Follow-Up Studies ; Health aspects ; Health risk assessment ; Health surveys ; Humans ; Investigations ; Longitudinal Studies ; Male ; Medical records ; Medicin och hälsovetenskap ; Memory ; Middle Aged ; Neuropathology ; Nitrogen dioxide ; Nitrogen Oxides - analysis ; Older people ; Outdoor air quality ; Pollutants ; Prospective Studies ; Risk Factors ; Studies ; Sweden - epidemiology ; Vehicle Emissions - analysis ; Vehicle Emissions - toxicity ; Womens health
É parte de: Environmental health perspectives, 2016-03, Vol.124 (3), p.306-312
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Exposure to ambient air pollution is suspected to cause cognitive effects, but a prospective cohort is needed to study exposure to air pollution at the home address and the incidence of dementia. We aimed to assess the association between long-term exposure to traffic-related air pollution and dementia incidence in a major city in northern Sweden. Data on dementia incidence over a 15-year period were obtained from the longitudinal Betula study. Traffic air pollution exposure was assessed using a land-use regression model with a spatial resolution of 50 m × 50 m. Annual mean nitrogen oxide levels at the residential address of the participants at baseline (the start of follow-up) were used as markers for long-term exposure to air pollution. Out of 1,806 participants at baseline, 191 were diagnosed with Alzheimer's disease during follow-up, and 111 were diagnosed with vascular dementia. Participants in the group with the highest exposure were more likely than those in the group with the lowest exposure to be diagnosed with dementia (Alzheimer's disease or vascular dementia), with a hazard ratio (HR) of 1.43 (95% CI: 0.998, 2.05 for the highest vs. the lowest quartile). The estimates were similar for Alzheimer's disease (HR 1.38) and vascular dementia (HR 1.47). The HR for dementia associated with the third quartile versus the lowest quartile was 1.48 (95% CI: 1.03, 2.11). A subanalysis that excluded a younger sample that had been retested after only 5 years of follow-up suggested stronger associations with exposure than were present in the full cohort (HR = 1.71; 95% CI: 1.08, 2.73 for the highest vs. the lowest quartile). If the associations we observed are causal, then air pollution from traffic might be an important risk factor for vascular dementia and Alzheimer's disease.
Editor: United States: National Institute of Environmental Health Sciences
Idioma: Inglês

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Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study

Oudin, Anna ; Forsberg, Bertil ; Adolfsson, Annelie Nordin ; Lind, Nina ; Modig, Lars ; Nordin, Maria ; Nordin, Steven ; Adolfsson, Rolf ; Nilsson, Lars-Göran

United States: National Institute of Environmental Health Sciences

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