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Transcervical sonography and human papillomavirus 16 E6 antibodies are sensitive for the detection of oropharyngeal cancer

Lang Kuhs, Krystle A. ; Wood, C. Burton ; Wiggleton, Jamie ; Aulino, Joseph M. ; Latimer, Brian ; Smith, Derek K. ; Bender, Noemi ; Rohde, Sarah ; Mannion, Kyle ; Kim, Young ; Sinard, Robert ; Langerman, Alexander ; Fleischer, Arthur ; Fakhry, Carole ; Waterboer, Tim ; Netterville, James L.

Cancer, 2020-06, Vol.126 (11), p.2658-2665 [Periódico revisado por pares]

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Título:
Transcervical sonography and human papillomavirus 16 E6 antibodies are sensitive for the detection of oropharyngeal cancer
Autor: Lang Kuhs, Krystle A. ; Wood, C. Burton ; Wiggleton, Jamie ; Aulino, Joseph M. ; Latimer, Brian ; Smith, Derek K. ; Bender, Noemi ; Rohde, Sarah ; Mannion, Kyle ; Kim, Young ; Sinard, Robert ; Langerman, Alexander ; Fleischer, Arthur ; Fakhry, Carole ; Waterboer, Tim ; Netterville, James L.
Assuntos: Aged ; Antibodies ; Antibodies, Viral - blood ; Cancer ; Computed tomography ; Confidence intervals ; Diagnosis ; Diagnostic systems ; Female ; Human papillomavirus ; human papillomavirus (HPV) ; human papillomavirus 16 (HPV‐16) E6 antibodies ; human papillomavirus–driven oropharyngeal cancer (HPV‐OPC) ; Humans ; Male ; Medical imaging ; Middle Aged ; Oncogene Proteins, Viral - immunology ; Oncology ; Oral cancer ; Oropharyngeal cancer ; Oropharyngeal Neoplasms - diagnosis ; Oropharyngeal Neoplasms - diagnostic imaging ; Oropharyngeal Neoplasms - virology ; Patients ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Repressor Proteins - immunology ; Sensitivity ; Serology ; Squamous cell carcinoma ; Throat cancer ; Tomography ; Tonsil ; transcervical sonography ; Tumors ; Ultrasonic imaging ; Ultrasonography - methods ; ultrasound
É parte de: Cancer, 2020-06, Vol.126 (11), p.2658-2665
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Funding acquisition: KALK
Writing- original draft: KALK, CBW
Conceptualization: All authors
Investigation: All authors
Resources: All authors
Writing-review and editing: All authors
Software: KALK, DKK
Visualization: KALK, CBW, DKK
Data curation: KALK, CBW, NB, TW
Formal analysis: KALK, CBW, DKK, NB, TW
Supervision: KALK, CBW, JLN
Validation: All authors
Methodology: All authors
Project Administration: All authors
These authors contributed equally to this work
CRediT
Descrição: Background Human papillomavirus 16 (HPV‐16) E6 seropositivity is a promising early marker of human papillomavirus–driven oropharyngeal cancer (HPV‐OPC), yet more sensitive imaging modalities are needed before screening is considered. The objective of this study was to determine the sensitivity of transcervical sonography (TCS) for detecting clinically apparent HPV‐OPC in comparison with computed tomography (CT) and positron emission tomography (PET)/CT. Methods Fifty‐one patients with known or suspected HPV‐OPC without prior treatment underwent oropharyngeal TCS and blood collection (for HPV multiplex serology testing). Eight standard sonographic images were collected; primary‐site tumors were measured in 3 dimensions if identified. Each patient underwent a full diagnostic workup as part of standard clinical care. The pathologic details, HPV status, final staging, and imaging findings were ed from the medical record. The sensitivity of each imaging modality was compared with the final clinical diagnosis (the gold standard). Results Twenty‐four base of tongue cancers (47%), 22 tonsillar cancers (43%), and 2 unknown primary cancers (4%) were diagnosed; 3 patients (6%) had no tumors. All p16‐tested patients were positive (n = 47). Primary‐site tumors were correctly identified in 90.2% (95% confidence interval [CI], 78.6%‐96.7%) with TCS, in 69.4% (95% CI, 54.6%‐81.7%) with CT, and in 83.3% (95% CI, 68.6%‐93.0%) with PET/CT. TCS identified tumors in 10 of 14 cases missed by CT and recognized the absence of tumors in 3 cases for which CT or PET/CT was falsely positive. The smallest sonographically identified primary‐site tumor was 0.5 cm in its greatest dimension; the average size was 2.3 cm. Among p16‐positive patients, 76.1% (95% CI, 61.2%‐87.4%) were seropositive for HPV‐16 E6. Conclusions TCS and HPV‐16 E6 antibodies are sensitive for the diagnosis of HPV‐OPC. It is currently unclear what type of diagnostic workup for oropharyngeal cancer is most appropriate for evaluating human papillomavirus 16 E6–seropositive individuals. This article presents an evaluation of transcervical ultrasonography for the diagnosis of oropharyngeal cancer and shows that it is more sensitive than traditional imaging modalities.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Transcervical sonography and human papillomavirus 16 E6 antibodies are sensitive for the detection of oropharyngeal cancer

Lang Kuhs, Krystle A. ; Wood, C. Burton ; Wiggleton, Jamie ; Aulino, Joseph M. ; Latimer, Brian ; Smith, Derek K. ; Bender, Noemi ; Rohde, Sarah ; Mannion, Kyle ; Kim, Young ; Sinard, Robert ; Langerman, Alexander ; Fleischer, Arthur ; Fakhry, Carole ; Waterboer, Tim ; Netterville, James L.

United States: Wiley Subscription Services, Inc

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