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Gentiana scabra extracts stimulate glucagon-like peptide-1 secretion via G protein-coupled receptor pathway

Min-Hee Shin ; Hyo-Weon Suh ; Ki-Beom Lee ; 김기석 ; 양해정 ; 최은경 ; Yu Jeong Cho ; 송미연 ; 안광석 ; Hyeung-Jin Jang

BioChip Journal, 2012, 6(2), , pp.114-119 [Periódico revisado por pares]

Heidelberg: 한국바이오칩학회

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Título:
Gentiana scabra extracts stimulate glucagon-like peptide-1 secretion via G protein-coupled receptor pathway
Autor: Min-Hee Shin ; Hyo-Weon Suh ; Ki-Beom Lee ; 김기석 ; 양해정 ; 최은경 ; Yu Jeong Cho ; 송미연 ; 안광석 ; Hyeung-Jin Jang
Assuntos: Beta cells ; Biomedical Engineering and Bioengineering ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Diabetes mellitus ; G protein-coupled receptors ; Gentiana scabra ; Glucagon ; Glucagon-like peptide 1 ; Herbal medicine ; Insulin secretion ; Original Research ; Pharmacology ; Proteins ; Receptors ; Secretion ; Signal transduction ; Taste stimuli ; Umami ; 생물공학
É parte de: BioChip Journal, 2012, 6(2), , pp.114-119
Notas: G704-SER000001574.2012.6.2.005
Descrição: Glucagon-like peptide-1 (GLP-1) which secreted by enteroendocrine L cell have been issued as a therapeutic agent for type II diabetes mellitus, because of its function to stimulate insulin secretion in pancreatic β-cells. It is widely studied that sweet, bitter, and umami taste stimuli induce the secretion of GLP-1 in enteroendocrine L cell via G protein coupled receptor (GPCR) signaling pathway. Gentiana scabra (GS) is one of the bitter tasting herbal medicines which have been used in traditional oriental medicine to treat the diabetes mellitus. This study shows the GLP-1 secretion of the enteroendocrine L cell stimulated by stimulation of GS extractions through GPCR pathway. To examine the molecular mode-of-action, GLP-1 ELISA and microarray was performed. This study provides the understanding the possibility of GS used as a therapeutic herbal medicine for the type II diabetes.
Editor: Heidelberg: 한국바이오칩학회
Idioma: Coreano;Inglês

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Gentiana scabra extracts stimulate glucagon-like peptide-1 secretion via G protein-coupled receptor pathway

Min-Hee Shin ; Hyo-Weon Suh ; Ki-Beom Lee ; 김기석 ; 양해정 ; 최은경 ; Yu Jeong Cho ; 송미연 ; 안광석 ; Hyeung-Jin Jang

Heidelberg: 한국바이오칩학회

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