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Functional synapse formation between compartmentalized cortical neurons cultured inside microfluidic devices

Sanjeev Kumar Mahto ; 송휴섭 ; 이석우

BioChip Journal, 2011, 5(4), , pp.289-298 [Periódico revisado por pares]

Heidelberg: 한국바이오칩학회

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  • Título:
    Functional synapse formation between compartmentalized cortical neurons cultured inside microfluidic devices
  • Autor: Sanjeev Kumar Mahto ; 송휴섭 ; 이석우
  • Assuntos: Axons ; Biomedical Engineering and Bioengineering ; Biomolecules ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Electrical stimuli ; Microenvironments ; Microfluidic devices ; Microfluidics ; Neurons ; Original Research ; Synapses ; Synaptogenesis ; 생물공학
  • É parte de: BioChip Journal, 2011, 5(4), , pp.289-298
  • Notas: G704-SER000001574.2011.5.4.001
  • Descrição: In this work, the formation of functional synapses between compartmentalized cortical neurons cultured inside three-compartment microfluidic devices in a controlled fashion is described. The proposed device can direct axons in an isolated compartment and, thus, facilitates isolated axons forming functional synapses with dendrites of other neurons in an isolated microenvironment. This microfluidic approach allows continuous real-time monitoring of neuronal processes and fluorescently tagged biomolecules involved in synapse formation, and provides an easy, simple, cost effective, and efficient method to develop and manipulate synapses in an isolated microenvironment without using surface patterning techniques or electrical stimulation. The results presented here suggest that this microfluidic approach could be used as an alternative method for the formation of functional synapses and their exhaustive examinations.
  • Editor: Heidelberg: 한국바이오칩학회
  • Idioma: Coreano;Inglês
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