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Age‐dependent increase of peritoneal B‐1b B cells in SCID mice

Hinkley, Kirk S. ; Chiasson, Rod J. ; Prior, Tracey K. ; Riggs, James E.

Immunology, 2002-02, Vol.105 (2), p.196-203 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

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  • Título:
    Age‐dependent increase of peritoneal B‐1b B cells in SCID mice
  • Autor: Hinkley, Kirk S. ; Chiasson, Rod J. ; Prior, Tracey K. ; Riggs, James E.
  • Assuntos: AB-1b cells ; Aging - immunology ; Animals ; B-Lymphocyte Subsets - immunology ; CD5 Antigens - analysis ; Cellular Senescence - immunology ; Immunoglobulins - biosynthesis ; Macrophage-1 Antigen - analysis ; Mice ; Mice, SCID ; Original ; Peritoneal Cavity - cytology ; Severe Combined Immunodeficiency - immunology ; Spleen - immunology
  • É parte de: Immunology, 2002-02, Vol.105 (2), p.196-203
  • Notas: Ortho McNeil Pharmaceutical Research Institute, Somerville, NJ, USA.
    Pennsylvania State University Medical School, Hershey, PA, USA
    Orchid BioScience, Princeton, NJ, USA
    Present addresses
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    Present addresses: Pennsylvania State University Medical School, Hershey, PA, USA
  • Descrição: Summary The impact of increasing age upon immunoglobulin production and B‐lymphocyte generation in ‘leaky’ severe combined immune‐defective (SCID) mice was examined by enzyme‐linked immunosorbent assay and flow cytometry. By 1 year of age, the mice had normal numbers of B cells in their peritoneal cavity, while their spleen had very few immunoglobulin M‐positive (IgM+) cells. The majority of B cells expressed the CD11b marker characteristic of the B‐1b subset. B‐1a (CD5+) cells were present at a lower frequency and B‐2 cells were absent. The frequency of mice producing detectable immunoglobulin increased with age, and isotype diversity within individual mice was variable. IgM production was most frequently observed followed by IgG3 and IgG2a, then IgG1, and finally IgA. The selective persistence of the B‐1 B‐cell subset in the peritoneal cavity of aging SCID mice is a natural model for the study of those genetic and environmental influences that determine lymphocyte longevity.
  • Editor: Oxford, UK: Blackwell Science Ltd
  • Idioma: Inglês
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