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Antinociceptive Effects of Interleukin-4, -10, and -13 on the Writhing Response in Mice and Zymosan-Induced Knee Joint Incapacitation in Rats

Vale, Mariana L ; Marques, Jaciara B ; Moreira, Camila A ; Rocha, Francisco Aírton C ; Ferreira, Sérgio H ; Poole, Stephen ; Cunha, Fernando Q ; Ribeiro, Ronaldo A

The Journal of pharmacology and experimental therapeutics, 2003-01, Vol.304 (1), p.102-108 [Periódico revisado por pares]

United States: American Society for Pharmacology and Experimental Therapeutics

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Título:
Antinociceptive Effects of Interleukin-4, -10, and -13 on the Writhing Response in Mice and Zymosan-Induced Knee Joint Incapacitation in Rats
Autor: Vale, Mariana L ; Marques, Jaciara B ; Moreira, Camila A ; Rocha, Francisco Aírton C ; Ferreira, Sérgio H ; Poole, Stephen ; Cunha, Fernando Q ; Ribeiro, Ronaldo A
Assuntos: Acetic Acid ; Analgesics - pharmacology ; Animals ; Antibodies, Blocking - pharmacology ; Arthritis, Experimental - chemically induced ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - pathology ; Behavior, Animal - drug effects ; Interleukin-1 - biosynthesis ; Interleukin-10 - antagonists & inhibitors ; Interleukin-10 - pharmacology ; Interleukin-13 - antagonists & inhibitors ; Interleukin-13 - pharmacology ; Interleukin-4 - antagonists & inhibitors ; Interleukin-4 - pharmacology ; Joints - pathology ; Male ; Mice ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Pain Measurement - drug effects ; Peritoneal Cavity - cytology ; Rats ; Reaction Time - drug effects ; Tumor Necrosis Factor-alpha - biosynthesis ; Zymosan
É parte de: The Journal of pharmacology and experimental therapeutics, 2003-01, Vol.304 (1), p.102-108
Descrição: The antinociceptive effects of interleukin (IL)-4, -10, and -13 were investigated in two different experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1â5 ng/animal), IL-10 (0.4â10 ng/animal), or IL-13 (0.4â2.5 ng/animal) inhibited the writhing response induced by the i.p. administration of acetic acid (53â89%) or zymosan (63â74%) in mice, and the knee joint incapacitation induced by i.a. injection of zymosan (49â66%) in rats. Neither of the cytokines affected the pain elicited in mice using the hot-plate test. This analgesic effect of IL-4, -10, and -13 was not reversed by the combined pretreatment with the opioid receptor antagonist naloxone. IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)-Î± (60, 53, and 100%, respectively) and IL-1Î² (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan. Antisera against IL-4, -10, and -13 potentiated both the zymosan-induced writhing response and the articular incapacitation. Our results demonstrate that IL-4, -10, and -13 display analgesic activity that is probably not due to endogenous opioid release. This analgesic effect could be related to a peripheral mechanism, probably via the inhibition of the release of the pro-inflammatory cytokines TNF-Î± and IL-1Î² by resident peritoneal macrophages.
Editor: United States: American Society for Pharmacology and Experimental Therapeutics
Idioma: Inglês

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Antinociceptive Effects of Interleukin-4, -10, and -13 on the Writhing Response in Mice and Zymosan-Induced Knee Joint Incapacitation in Rats

Vale, Mariana L ; Marques, Jaciara B ; Moreira, Camila A ; Rocha, Francisco Aírton C ; Ferreira, Sérgio H ; Poole, Stephen ; Cunha, Fernando Q ; Ribeiro, Ronaldo A

United States: American Society for Pharmacology and Experimental Therapeutics

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