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Dengue fatal cases present virus-specific HMGB1 response in peripheral organs

Oliveira, Edson R A ; Póvoa, Tiago F ; Nuovo, Gerard J ; Allonso, Diego ; Salomão, Natália G ; Basílio-de-Oliveira, Carlos A ; Geraldo, Luiz H M ; Fonseca, Celina G ; Lima, Flávia R S ; Mohana-Borges, Ronaldo ; Paes, Marciano V

Scientific reports, 2017-11, Vol.7 (1), p.16011-14, Article 16011 [Periódico revisado por pares]

England: Nature Publishing Group

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Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
Autor: Oliveira, Edson R A ; Póvoa, Tiago F ; Nuovo, Gerard J ; Allonso, Diego ; Salomão, Natália G ; Basílio-de-Oliveira, Carlos A ; Geraldo, Luiz H M ; Fonseca, Celina G ; Lima, Flávia R S ; Mohana-Borges, Ronaldo ; Paes, Marciano V
Assuntos: Adult ; Apoptosis ; Cardiomyocytes ; Cell death ; Cytokines ; Cytokines - metabolism ; Cytoplasm ; Dengue - metabolism ; Dengue - pathology ; Dengue fever ; Dengue hemorrhagic fever ; Dengue Virus - pathogenicity ; Female ; Heart ; Histopathology ; HMGB1 protein ; HMGB1 Protein - genetics ; HMGB1 Protein - metabolism ; Humans ; Immunohistochemistry ; Immunopathogenesis ; In Situ Hybridization ; In Situ Nick-End Labeling ; Infectious diseases ; Inflammation ; Inflammation - metabolism ; Investigations ; Liver ; Male ; Microscopy ; Microscopy, Electron ; Middle Aged ; Morphology ; Pathogenesis ; Pathogens ; Permeability ; Ribonucleic acid ; RNA ; Young Adult
É parte de: Scientific reports, 2017-11, Vol.7 (1), p.16011-14, Article 16011
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SourceType-Scholarly Journals-1
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Descrição: Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite its epidemiological relevance, there are many knowledge gaps concerning dengue pathogenesis, especially with regards to the circumstances that drive a mild clinical course to a severe disease. In this work, we investigated the participation of high mobility group box 1 (HMGB1), an important modulator of inflammation, in dengue fatal cases. Histopathological and ultrastructural analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities, such as necrosis and apoptotic cell death. These observations go in line with an HMGB1-mediated response and raised concerns regarding the participation of this cytokine in promoting/perpetuating inflammation in severe dengue. Further experiments of immunohistochemistry (IHC) showed increased expression of cytoplasmic HMGB1 in dengue-extracted tissues when compared to non-dengue controls. Co-staining of DENV RNA and HMGB1 in the host cell cytoplasm, as found by in situ hybridization and IHC, confirmed the virus specific induction of the HMGB1-mediated response in these peripheral tissues. This report brings the first in-situ evidence of the participation of HMGB1 in severe dengue and highlights novel considerations in the development of dengue immunopathogenesis.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Dengue fatal cases present virus-specific HMGB1 response in peripheral organs

Oliveira, Edson R A ; Póvoa, Tiago F ; Nuovo, Gerard J ; Allonso, Diego ; Salomão, Natália G ; Basílio-de-Oliveira, Carlos A ; Geraldo, Luiz H M ; Fonseca, Celina G ; Lima, Flávia R S ; Mohana-Borges, Ronaldo ; Paes, Marciano V

England: Nature Publishing Group

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