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Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

Abdulmawjood, Bilal ; Costa, Beatriz ; Roma-Rodrigues, Catarina ; Baptista, Pedro V ; Fernandes, Alexandra R

International journal of molecular sciences, 2021-11, Vol.22 (22), p.12516 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?
Autor: Abdulmawjood, Bilal ; Costa, Beatriz ; Roma-Rodrigues, Catarina ; Baptista, Pedro V ; Fernandes, Alexandra R
Assuntos: Abnormalities ; Apoptosis ; beta Catenin - genetics ; Biomarkers, Tumor - genetics ; Blast Crisis - genetics ; Blast Crisis - pathology ; Cell adhesion ; Chromosome aberrations ; Chromosomes ; Chronic myeloid leukemia ; DNA methylation ; Epidermal growth factor ; ErbB Receptors - genetics ; Fusion protein ; Genes ; genetic biomarkers ; Genomic instability ; Genomic Instability - genetics ; Growth factors ; Hematopoietic system ; Humans ; Kinases ; Leukemia ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology ; miRNA ; miRNAs ; Mutation ; Myeloid leukemia ; p53 Protein ; Pathogenesis ; Philadelphia Chromosome ; Proto-Oncogene Proteins pp60(c-src) - genetics ; Reactive Oxygen Species - metabolism ; Review ; Ski protein ; Transforming Growth Factor beta1 - genetics ; Transforming growth factor-b1 ; Tumor necrosis factor-α ; Tumor Suppressor Protein p53 - genetics
É parte de: International journal of molecular sciences, 2021-11, Vol.22 (22), p.12516
Descrição: Chronic Myeloid Leukemia (CML) is a rare malignant proliferative disease of the hematopoietic system, whose molecular hallmark is the Philadelphia chromosome (Ph). The Ph chromosome originates an aberrant fusion gene with abnormal kinase activity, leading to the buildup of reactive oxygen species and genetic instability of relevance in disease progression. Several genetic abnormalities have been correlated with CML in the blast phase, including chromosomal aberrations and common altered genes. Some of these genes are involved in the regulation of cell apoptosis and proliferation, such as the epidermal growth factor receptor ( ) tumor protein p53 ( ), or Schmidt-Ruppin A-2 proto-oncogene ( ); cell adhesion, e.g., catenin beta 1 ( ); or genes associated to TGF-β, such as SKI like proto-oncogene ( ), transforming growth factor beta 1 ( ) or transforming growth factor beta 2 ( ); and TNF-α pathways, such as Tumor necrosis factor ( ) or Nuclear factor kappa B subunit 1 ( ). The involvement of miRNAs in CML is also gaining momentum, where dysregulation of some critical miRNAs, such as miRNA-451 and miRNA-21, which have been associated to the molecular modulation of pathogenesis, progression of disease states, and response to therapeutics. In this review, the most relevant genomic alterations found in CML will be addressed.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

Abdulmawjood, Bilal ; Costa, Beatriz ; Roma-Rodrigues, Catarina ; Baptista, Pedro V ; Fernandes, Alexandra R

Switzerland: MDPI AG

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